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Disease research

SARS-CoV-2 viral particle in crosshares with words 'target locked' above

news

SARS-CoV-2 papain-like protease could be a novel drug target

19 October 2020 | By Hannah Balfour (Drug Target Review)

Scientists suggest targeting the SARS-CoV-2 papain-like protease (PLpro) with inhibitors could prevent the spread of infection.

whitepaper

Application note: Phenotypic characterisation of neuroactive compound effects

19 October 2020 | By Molecular Devices

Learn how to perform complex analysis of calcium oscillations and assess cellular and mitochondrial toxicity.

cartoon of scientists in a lab looking at the genome and conducting experiments

article

Could GPCRs be causing people to respond differently to the same drug?

16 October 2020 | By Hannah Balfour (Drug Target Review)

Hannah Balfour explores how genetic variation in G-protein-coupled receptors (GPCRs) and the proteins that regulate the duration of G protein signalling could be contributing to disease and people’s divergent responses to the same therapeutics.

RNA strand on an abstract orange swirling background

news

Long non-coding RNAs could be future targets for cancer drugs

16 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers have implicated long non-coding RNAs in tumour progression and suggest they may be potential drug targets for cancers with p53 mutations.

news

Targeting host proteins could lead to pan-coronavirus antivirals

16 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers suggest that targeting host proteins with drugs, rather than directly targeting enzymes or proteins on SARS-CoV-2 and related coronaviruses, could improve outcomes.

man holding the front of his head with the temporal lobe of the brain highlighted in red

news

D-serine could protect against epileptic seizures

15 October 2020 | By Hannah Balfour (Drug Target Review)

Scientist identified the mechanism through which temporal lobe epileptic seizures are sparked and that D-serine can interfere with this process, preventing seizures.

news

Study reveals roles of antibodies in SARS-CoV-2 disease severity

15 October 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that the level of antibodies in the serum of SARS-CoV-2 patients correlated with disease severity.

news

Over 200 molecules and genes linked to COVID-19 severity

14 October 2020 | By Victoria Rees (Drug Target Review)

A team has identified 219 molecules and genes that influence the severity of COVID-19 in patients, providing information that could aid the development of therapeutics.

whitepaper

Whitepaper: The impact of COVID-19 on neurological systems

13 October 2020 | By PerkinElmer

Neurological symptoms have been observed in COVID-19 patients. The link between SARS-CoV-2 and the CNS is critical to developing effective treatments

video

Video: Gain deeper insights into cellular 3D structures with water immersion objectives

13 October 2020 | By Molecular Devices

Water immersion objectives are essential for capturing more data at greater depths in 3D structures, such as spheroids and thick tissues.

news

COVID-19 vaccines should not be affected by SARS-CoV-2 mutations, researchers say

12 October 2020 | By Victoria Rees (Drug Target Review)

A common SARS-CoV-2 mutation known as D614G should not impact on the efficacy of COVID-19 vaccines, a study has shown.

Assess transduction efficiency of CFP-tagged nuclear protein with automated cellular imaging

whitepaper

Application note: Assess transduction efficiency of CFP-tagged nuclear protein with automated cellular imaging

12 October 2020 | By Molecular Devices

Evaluating and quantitating nuclear transduction.

SARS-CoV-2 particles in grey and red - SARS-CoV-2 is the virus that causes COVID-19

news

Researchers suggest blocking factor D protein could combat SARS-CoV-2

9 October 2020 | By Victoria Rees (Drug Target Review)

A team has said that inhibiting the factor D protein could prevent SARS-CoV-2 from turning the immune system against healthy cells.

purpley-blue antibodies surrounding a red and black SARS-CoV-2 viral particle

news

SARS-CoV-2-targeting antibodies persist for at least three months in COVID-19 patients

9 October 2020 | By Hannah Balfour (Drug Target Review)

Two separate studies show that IgG serotype antibodies targeting the SARS-CoV-2 spike protein are still detectable in patient’s blood and saliva after 90 days.

EEG waves indicating an epileptic seizure overlaid with a brain

news

Single-nucleus transcriptomics reveals novel epilepsy targets

8 October 2020 | By Hannah Balfour (Drug Target Review)

Study reveals which neurons are most affected by epilepsy, presenting novel targets for seizure drug discovery and development.

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Disease research