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Disease research

SARS-CoV-2 particles infecting a human cell

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Lysosomes key to coronavirus shedding, finds study

29 October 2020 | By Hannah Balfour (Drug Target Review)

Scientists reveal that coronaviruses de-activate lysosomes before using them to exit infected cells and spread through the body.

news

Leveraging flow cytometry to explore COVID-19 immune responses

29 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers used flow cytometry to characterise which types of T cells are involved in the immune response to COVID-19 and what they target.

cells in blue and green on a dark background

news

Cellular senescence as a drug target

27 October 2020 | By Hannah Balfour (Drug Target Review)

New research reveals that age-related declines in cellular function and proliferation occur in multiple stages, accompanied by different inflammatory responses.

whitepaper

ebook: Phenotypic screening with iPSC-derived cardiomyocytes and neurons

27 October 2020 | By Molecular Devices

Identify therapeutic effects and adverse responses to compounds earlier in the drug discovery process.

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Analysis of mouse neuroinflammation samples aided by flow cytometry

26 October 2020 | By Victoria Rees (Drug Target Review)

A new study has highlighted the advantages of using flow cytometry for the analysis of neuroimmune cell populations from mouse models.

news

New imaging method reveals glycan vaccine targets on HIV molecules

26 October 2020 | By Victoria Rees (Drug Target Review)

Using cryo-electron microscopy and site-specific mass spectrometry, researchers have mapped the glycans that shield HIV from the immune system.

whitepaper

ebook: Eliminate 50/60 Hz line-frequency noise in less than one second

26 October 2020 | By Molecular Devices

A major challenge within electrophysiology labs is 50 or 60 Hz line frequency electrical noise, which can either distort or completely drown out biological signal.

video

On-demand webinar: Complete workflow solution from gene-to-protein

23 October 2020 | By thermo fisher scientific – synthetic biology

Our full gene-to-protein workflow can support your research for rapid protein production early during drug development so you can minimize changes from R&D to bioproduction.

news

Flow cytometry market to exhibit CAGR of 12 percent

23 October 2020 | By Victoria Rees (Drug Target Review)

A new report has said that by 2023, the flow cytometry market will be worth $8.88 billion, partly due to an increase in stem cell research.

Outline of lungs and SARS-CoV-2 particles

news

Mini lung organoids reveal early SARS-CoV-2 infection process

23 October 2020 | By Victoria Rees (Drug Target Review)

Using lung organoids, researchers have shown that 48 hours after SARS-CoV-2 infection, the innate immune response began.

A coiling protein 'shell,' called a nucleocapsid, shown here, surrounds Ebola's genetic material, which consists of single-strand RNA. University of Delaware researchers are simulating the way molecules of this nucleocapsid move and interact, atom by atom, to understand their functions and expose targets for anti-viral treatments [Credit: Juan Perilla Laboratory].

news

The nucleocapsid as a novel drug target for Ebola virus

22 October 2020 | By Hannah Balfour (Drug Target Review)

Using supercomputer stimulations researchers reveal that the structural stability of the Ebola nucleocapsid is depended on the presence of RNA and interactions with charged ions.

news

Novel anti-inflammatory slows progression of MS in mice

22 October 2020 | By Hannah Balfour (Drug Target Review)

When delivered intranasally, the anti-inflammatory drug VX-765 prevented axon demyelination and loss in a murine model of multiple sclerosis (MS).

SARS-CoV-2 particles in red over a research background - microscope, connical flask and test tubes in grey

news

Severe COVID-19 symptoms may not be caused by cytokine storm

22 October 2020 | By Hannah Balfour (Drug Target Review)

An analysis reveals that in comparison to other inflammatory diseases such as cytokine-release syndrome (CRS) and sepsis, the levels of cytokines in severely ill COVID-19 patients is low.

SARS-CoV-2 particles entering human cells

news

SARS-CoV-2 also uses neuropilin-1 to infect human cells

21 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers reveal that SARS-CoV-2 is more infectious than SARS-CoV because it can use both ACE2 and neuropilin-1 to infect cells.

whitepaper

Webinar: High-content analysis and phenotypic characterisation of 2D and 3D cellular models

20 October 2020 | By Molecular Devices

Combining 2D and 3D models with live-cell assays allows monitoring of cell responses in real time and provides important insights about compound treatment effects, biological complexity, and physiological relevance of assay results.

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Disease research