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Disease research

cartoon of two hips and femurs - left on with large black dots in the bone indicating osteoporosis (bone being removed and becoming spongy), the other with smaller dots indicating normal bone

news

MALP cells as a potential target for osteoporosis drug development

23 November 2020 | By Hannah Balfour (Drug Target Review)

Researchers have found that bone marrow adipogenic lineage precursor (MALP) cells may initiate the production of osteoclasts and drive bone remodelling in osteoporosis.

news

Drug target and candidate for paediatric heart failure identified

23 November 2020 | By Victoria Rees (Drug Target Review)

A group of researchers has found a drug candidate named TRV027 that can increase the cardiac contractility of neonatal mice.

news

Researchers reveal how coronaviruses use protein vibrations to enter cells

23 November 2020 | By Victoria Rees (Drug Target Review)

Using atomistic simulations, a team has demonstrated how coronavirus Spike proteins move and vibrate to let the virus through cell walls.

close up of a man's ear with a hearing aid in - idea of deafness

article

Promising targets for deafness drug discovery

23 November 2020 | By Hannah Balfour (Drug Target Review)

In this article, Janssen Pharmaceuticals’ Global Head of Discovery Neuroscience discusses the findings of their recent study which highlighted new roles for two gene products involved in human deafness which could enable drug discovery for some prevalent auditory disorders.

hand holding a black rimmed magnifying glass over a DNA strand - idea of genetic research

news

Mutated PCSK9 gene protects against liver damage and cardiovascular disease, say researchers

20 November 2020 | By Hannah Balfour (Drug Target Review)

Scientists suggest the PCSK9Q152H gene variant may act as a “fountain of youth”, allowing people to live longer, healthier lives.

alveoli with blue SARS-CoV-2 particles (spiky balls) inside

news

Mini lung organoids replicate COVID-19 pathology in a dish

20 November 2020 | By Hannah Balfour (Drug Target Review)

Scientists developed a new culture technique for alveolospheres which they used to study how alveolar cells respond to SARS-CoV-2 infection.

news

£4 million in funding announced to collect data on COVID-19 antibodies

19 November 2020 | By Victoria Rees (Drug Target Review)

UKRI will provide £4 million in funding to establish a data infrastructure for scientists in the UK to study antibodies from COVID-19 patient samples.

news

Potential strategy to treat COVID-19-related cytokine storms identified

19 November 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that neutralising antibodies for the TNF-alpha and IFN-gamma cytokines can prevent death from SARS-CoV-2 in mice.

Computer recreation of dopaminergic neurons (involved in Parkinson's) in blue and pink

news

Novel technique reveals Parkinson’s changes how neurons sense oxygen

17 November 2020 | By Hannah Balfour (Drug Target Review)

The new approach enables researchers to isolate brain cells associated with Parkinson's disease and study their gene expression patterns.

cancerous cell with crosshares over it - idea of targetted cancer therapy

news

LMTK3 inhibitors could be an effective breast cancer therapy, say scientists

16 November 2020 | By Hannah Balfour (Drug Target Review)

Researchers demonstrate that inhibiting the LMTK3 kinase is an effective anticancer strategy in murine models of breast cancer.

news

Primate model used to explore features of SARS-CoV-2 infection

16 November 2020 | By Hannah Balfour (Drug Target Review)

The non-human primate model exhibited a COVID-19-like disease and showed how symptoms and viral activity change over the course of SARS-CoV-2 infection.

news

Researchers suggest SKI complex of SARS-CoV-2 as novel drug target

16 November 2020 | By Victoria Rees (Drug Target Review)

Researchers have discovered new drug compounds that target the SKI complex of SARS-CoV-2, preventing replication.

X-ray of the back of human hands with joints highlighted in red - idea of joint inflammation due to arthritis

news

Researchers dicover novel targets for rheumatoid arthritis therapies

13 November 2020 | By Hannah Balfour (Drug Target Review)

Researchers have identified that autoreactive B cells and a protein that enables them to invade joints could be promising drug targets for the most common inflammatory arthritis.

news

Researchers reveal structure of SARS-CoV-2 Envelope protein

13 November 2020 | By Victoria Rees (Drug Target Review)

The molecular structure of the SARS-CoV-2 Envelope protein has been identified by researchers using nuclear magnetic resonance.

SARS-CoV-2 spike protein bound to an ACE2 receptor on the cell surface

news

Furin cleavage motif makes SARS-CoV-2 more aggressive than other CoVs, find scientists

12 November 2020 | By Hannah Balfour (Drug Target Review)

A specific furin cleavage motif on the SARS-CoV-2 Spike protein, not present on other coronaviruses (CoVs), could be targeted by novel COVID-19 therapies.

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Disease research