List view / Grid view

CRISPR

news

Modified CRISPR technique used to combat Parkinson’s disease

13 October 2017 | By Dr Zara Kassam (Drug Target Review)

Biological engineers identify genes that protect against protein linked to Parkinson's disease...

news

Microcapsules to enhance the efficiency of genome-editing

6 October 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have found that polymer and hybrid silica-coated microcapsules are efficient in genome-editing...

news

CRISPR-engineered cancer model to test therapeutics

5 October 2017 | By Dr Zara Kassam (Drug Target Review)

A new technique for modelling leukaemia may aid drug discovery...

news

CRISPR-Cas9 used to systematically inactivate genes in colorectal cancer

28 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used CRISPR-Cas9 to inactivate genes in human colorectal cancer cell lines -- one with normal KRAS gene and one with a mutant KRAS...

news

Genome editing reveals a role for OCT4 in human embryogenesis

21 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used genome editing technology to reveal the role of a key gene in human embryos in the first few days of development...

news

GREB1L mutations associated with renal agenesis

19 September 2017 | By Dr Zara Kassam (Drug Target Review)

A team of researchers has identified the mutated gene GREB1L is linked to renal agenesis...

news

CRISPR-Cas9 technology used to study hereditary forms of cancer

14 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have developed a method, based on CRISPR-Cas9 technology in organoids, to study the genetic cause of hereditary forms of cancer...

article

Expert view: Effective coupling of assays and cell models

11 September 2017 | By Steven G Jarvis (Head of Pharma & Biotech Segment Strategy - MilliporeSigma)

Assay robustness tends to be the favoured descriptor when a particular assay can cope with minute changes in the sample, equipment, or operator. The more robust an assay, the more predictive data it ultimately yields. The industry’s greatest challenge for assay development has always been using those robust assays to…

news

CRISPR gives new insight into autoimmune disorders

1 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used a modified version of the gene-editing technique CRISPR in search for gene activators...

news

Scientists characterise regulatory DNA sequences responsible for human diseases

25 August 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have developed an innovative system to identify and characterise the molecular components that control the activities of regulatory DNA sequences...

news

CRISPR identifies essential genes for cancer immunotherapy

8 August 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used CRISPR to stop the expression of individual genes in cancer cells, by knocking out every known protein-encoding gene in the human genome...

article

CRISPR-Cas9 repairs genetic mutation in human embryos

3 August 2017 | By James Adjaye (Institute for Stem Cell Research and Regenerative Medicine), Justin Bryans, Steve Bremer (Drug Target Review)

"Well thought through and brilliantly executed" study shows different DNA-repair mechanism in embryos compared to iPSCs

David F Fischer, PhD, Executive Director Biology at Charles River

article

David F Fischer on target screening

10 July 2017 | By Drug Target Review

Drug Target Review editor Steve Bremer asks David F Fischer for his views on target discovery and validation in drug discovery. David F Fischer, PhD, is Executive Director Biology at Charles River...

article

New drug targets identified to defend against chlamydia infections using CRISPR and stem cells

7 July 2017 | By Amy Yeung (Wellcome Trust Sanger Institute)

Human induced pluripotent stem cell derived macrophages (iPSDMs) provide a cell-based model system to study chlamydia infection in the laboratory. Amy Yeung from Wellcome Trust Sanger Institute explains how she used this model in combination with CRISPR-Cas 9 technology to explore the potential of the two genes, IRF5 and IL10RA,…

news

CRISPR gene editing can cause hundreds of unintended mutations

30 May 2017 | By Niamh Marriott (Drug Target Review)

As CRISPR-Cas9 starts to move into clinical trials, a new study has found that the gene-editing technology can introduce hundreds of unintended mutations into the genome.

Cookie	Type	Duration	Description
cookielawinfo-checkbox-advertising-targeting	persistent	1 year	The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Advertising & Targeting".
cookielawinfo-checkbox-analytics	persistent	1 year	This cookie is set by GDPR Cookie Consent WordPress Plugin. The cookie is used to remember the user consent for the cookies under the category "Analytics".
cookielawinfo-checkbox-necessary	persistent	1 year	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-performance	persistent	1 year	This cookie is set by GDPR Cookie Consent WordPress Plugin. The cookie is used to remember the user consent for the cookies under the category "Performance".
PHPSESSID	session	1 year	This cookie is native to PHP applications. The cookie is used to store and identify a users' unique session ID for the purpose of managing user session on the website. The cookie is a session cookies and is deleted when all the browser windows are closed.
viewed_cookie_policy	persistent	1 year	The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
zmember_logged	session	1 year	This session cookie is served by our membership/subscription system and controls whether you are able to see content which is only available to logged in users.

Cookie	Type	Duration	Description
advanced_ads_browser_width	persistent	1 month	This cookie is set by Advanced Ads and measures the browser width.
advanced_ads_page_impressions	persistent	2 years	This cookie is set by Advanced Ads and measures the number of previous page impressions.
advanced_ads_pro_server_info	persistent	1 month	This cookie is set by Advanced Ads and sets geo-location, user role and user capabilities. It is used by cache busting in Advanced Ads Pro when the appropriate visitor conditions are used.
advanced_ads_pro_visitor_referrer	persistent	1 year	This cookie is set by Advanced Ads and sets the referrer URL.
bscookie	persistent	2 years	This cookie is a browser ID cookie set by LinkedIn share Buttons and ad tags.
IDE	persistent	2 years	This cookie is set by Google DoubleClick and stores information about how the user uses the website and any other advertisement before visiting the website. This is used to present users with ads that are relevant to them according to the user profile.
li_sugr	persistent	3 months	This cookie is set by LinkedIn and is used for tracking.
UserMatchHistory	persistent	1 month	This cookie is set by Linkedin and is used to track visitors on multiple websites, in order to present relevant advertisement based on the visitor's preferences.
VISITOR_INFO1_LIVE	persistent	5 months	This cookie is set by YouTube. Used to track the information of the embedded YouTube videos on a website.

Cookie	Type	Duration	Description
bcookie	persistent	2 years	This cookie is set by LinkedIn. The purpose of the cookie is to enable LinkedIn functionalities on the page.
GPS	persistent	30 minutes	This cookie is set by YouTube and registers a unique ID for tracking users based on their geographical location
lang	session	1 year	This cookie is set by LinkedIn and is used to store the language preferences of a user to serve up content in that stored language the next time user visit the website.
lidc	persistent	1 day	This cookie is set by LinkedIn and used for routing.
lissc	persistent	11 months	This cookie is set by LinkedIn share Buttons and ad tags.
vuid	persistent	2 years	We embed videos from our official Vimeo channel. When you press play, Vimeo will drop third party cookies to enable the video to play and to see how long a viewer has watched the video. This cookie does not track individuals.
wow.anonymousId	persistent	2 years	This cookie is set by Spotler and tracks an anonymous visitor ID.
wow.schedule	persistent	20 minutes	This cookie is set by Spotler and enables it to track the Load Balance Session Queue.
wow.session	persistent	20 minutes	This cookie is set by Spotler to track the Internet Information Services (IIS) session state.
wow.utmvalues	persistent	20 minutes	This cookie is set by Spotler and stores the UTM values for the session. UTM values are specific text strings that are appended to URLs that allow Communigator to track the URLs and the UTM values when they get clicked on.
_ga	persistent	2 years	This cookie is set by Google Analytics and is used to calculate visitor, session, campaign data and keep track of site usage for the site's analytics report. It stores information anonymously and assign a randomly generated number to identify unique visitors.
_gat	persistent	1 minute	This cookies is set by Google Universal Analytics to throttle the request rate to limit the collection of data on high traffic sites.
_gid	persistent	1 day	This cookie is set by Google Analytics and is used to store information of how visitors use a website and helps in creating an analytics report of how the website is doing. The data collected including the number visitors, the source where they have come from, and the pages visited in an anonymous form.

Cookie	Type	Duration	Description
cf_ob_info	persistent	1 minute	This cookie is set by Cloudflare content delivery network and, in conjunction with the cookie 'cf_use_ob', is used to determine whether it should continue serving “Always Online” until the cookie expires.
cf_use_ob	persistent	1 minute	This cookie is set by Cloudflare content delivery network and is used to determine whether it should continue serving “Always Online” until the cookie expires.
free_subscription_only	session	1 year	This session cookie is served by our membership/subscription system and controls which types of content you are able to access.
ls_smartpush	persistent	1 month	This cookie is set by Litespeed Server and allows the server to store settings to help improve performance of the site.
one_signal_sdk_db	persistent	Until cleared	This cookie is set by OneSignal push notifications and is used for storing user preferences in connection with their notification permission status.
YSC	session	1 year	This cookie is set by Youtube and is used to track the views of embedded videos.

Recommended

CRISPR