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Single enzyme provides target for new sepsis drugs

14 August 2019 | By Rachael Harper (Drug Target Review)

Researchers have discovered that removing the enzyme, PHLPP1, improves outcomes in a mouse model of sepsis so could be a potential drug target.

news

Protective protein guards against DNA damage

5 August 2019 | By Rachael Harper (Drug Target Review)

It has been discovered that Polo-like kinase (PLK1) guards against severe DNA damage and could help target fast-growing cancer cells.

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OX40-expressing follicular helper T cells can control rheumatoid arthritis

1 August 2019 | By Rachael Harper (Drug Target Review)

New study shows that a subset of follicular helper T cells contributes to the hyposialylation of autoantibodies in rheumatoid arthritis.

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Newly discovered signal could lead to anti-cancer therapies

31 July 2019 | By Drug Target Review

Researchers have newly found that protein CD24 acts as a defensive signal and is used by cancer cells to protect themselves.

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Transfer of oncogene in colon cancer cells demonstrated

22 July 2019 | By Drug Target Review

A new study has shown that proteins derived from the oncogene, KRAS, can transfer between colon cancer cells.

whitepaper

Whitepaper: IHC/ICC Protocol Guide

22 July 2019 | By Bio-Techne

Immunohistochemistry (IHC) and immunocytochemistry (ICC) are techniques employed to localize antigen expression and are dependent on specific epitope-antibody interactions.

whitepaper

Whitepaper: Neural Cell Culturing Guide

22 July 2019 | By Bio-Techne

The advent of in vitro culturing of neural cells has been central to driving our understanding of the nervous system.

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Omega-6 fatty acid could help fight heart disease

19 July 2019 | By Drug Target Review

Scientists have shown that an omega-6 polyunsaturated fatty acid could halt the progression of atherosclerosis, a leading cause of heart disease.

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New evidence shows cytotoxic T cells can destroy targets of large mass

10 July 2019 | By Drug Target Review

New study shows the ability of CD8+ cytotoxic T cells to penetrate a large target, which opens avenues to destroy solid cancers.

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Secondary structures study could lead to making cancer cells vulnerable

9 July 2019 | By Drug Target Review

Researchers have used machine learning to discover that the two most widespread DNA structures cause genome mutations that lead to cancer.

news

New discovery shows ability of Schwann cells to generate myelin

8 July 2019 | By Drug Target Review

Research from Oregon Health & Science University could lead to new therapies to heal nervous system disorders.

news

Stem cell stimulation shown to improve stroke recovery

2 July 2019 | By Drug Target Review

Stem cell stimulation shows promise as a potential noninvasive stroke treatment.

news

Light-stimulated brain cells could aid in stroke recovery research

1 July 2019 | By Drug Target Review

A new 'optochemogenetics' research approach from scientists at the Emory University School of Medicine could aid in helping stroke victims.

news

Protective antibodies identified that could be key to malaria vaccine

18 June 2019 | By Drug Target Review

A new study has identified antibodies that may hold the key to creating the first effective vaccine against malaria infection in the blood.

news

First blood-brain barrier chip using stem cells developed

13 June 2019 | By Drug Target Review

Researchers have, for the first time, duplicated a patient's blood-brain barrier (BBB), creating a human BBB chip with stem cells.

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