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Cell-based assays

ProteinSimple NanoPro 1000

2 December 2015 | By ProteinSimple

Simple Western™ system for the characterization of post-translational protein modification by the detection of charge isoforms...

news

Experimental Alzheimer’s drug J147 shows anti-aging effects

13 November 2015 | By Victoria White

Mice treated with J147 had better memory and cognition, healthier blood vessels in the brain and other improved physiological features...

Exploiting functional selectivity of GPCRs in drug development

article

Exploiting functional selectivity of GPCRs in drug development

21 September 2015 | By Niklas Larsson (AstraZeneca), Torben Østerlund (AstraZeneca)

The large family of pharmaceutical targets represented by G-protein coupled receptors (GPCRs) are usually involved in a number of intracellular effector pathways, leading to many cellular outcomes. In recent years it has been uncovered that different ligands of a given GPCR may engage the pathways selectively, in that ligands that…

news

TxCell announces preclinical efficacy results for Col-Treg in autoimmune uveitis

9 September 2015 | By Victoria White

In vivo administration of Col-Treg in the model of autoimmune uveitis significantly inhibited clinical symptoms, retinal tissue lesions as well as ocular proinflammatory cell infiltration...

news

Douglas Scientific and TATAA Biocenter announce Tumour Cell Profiling Study contest

8 July 2015 | By Victoria White

Douglas Scientific is sponsoring a Tumor Cell Profiling Study for up to three researchers as part of a collaborative partnership with TATAA Biocenter...

article

Evaluation of a GADD45a-GFP human cell assay for rapid and reliable in vitro early genotoxicity screening

9 April 2015 | By Anne-Pascale Luzy (Galderma R&D), Guy Bouvier (Galderma R&D), Jean-Michel Linget (Galderma R&D), Nicolas Orsini (Galderma R&D)

This article evaluates a GADD45a-GFP human cell assay for rapid and reliable in vitro early genotoxicity screening...

article

Workshop Review: Cell-based Assays for Screening (December 2014)

9 April 2015 | By Sheraz Gul (Fraunhofer-IME SP)

Sheraz Gul, Head of Biology at Fraunhofer-IME SP, provides an in-depth review of the Cell-Based Assays for Screening workshop which took place in December 2014...

news

Event preview: Drug Discovery Week Europe

3 October 2014 | By GTCbio

From 7-10 October 2014, GTCbio will proudly present its Drug Discovery Week Europe event in the beautiful city of Dublin, Ireland...

article

Collaborative drug discovery: an update on the progress of such initiatives

29 October 2013 | By Sheraz Gul (Fraunhofer-IME SP)

Despite the ever increasing efforts being expended for drug discovery purposes, the number of approved drugs remains relatively static. A variety of explanations have been provided to explain this observation and initiatives to remedy this situation have been implemented. Many of these initiatives are still works-in-progress and whether these will…

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Cell-based assays