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Article: Common CRISPR pitfalls and how to avoid them
This article explains how to plan a gene-editing experiment. How to choose your biological system and what reagents to get for your experimental aim.
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Biopharmaceuticals
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Antibodies In-Depth Focus 2020
Included in this in-depth focus are articles on antibody therapeutics to treat COVID-19, how AAV antibodies can be neutralised, the role of antibodies in cancer therapy and bispecific antibodies for immuno-oncology drugs.
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Application note: Human iPS cells modified with Edit-R™ CRISPR-Cas9 reagents
Modify the genome and modulate expression of genes within human iPS cells with Dharmacon™ Edit-R CRISPR reagents.
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Untangling gene expression complexity with pooled CRISPR screens coupled to single-cell transcriptome analysis
4 September 2020 | By Horizon Discovery
During this on-demand webinar we present data showing how Horizon’s CRISPRsc screening platform offers a streamlined approach to elucidating valuable and intriguing biological information that is critical to resolving complex biological questions.
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Method to synthetically produce terpenes developed by researchers
Scientists have developed a synthetic biology process using enzymes to create three families of terpenes, potential starting points for new drugs.
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Webinar: HCP assays to improve risk mitigation
HCPs are critical to quality control in biologics development. If left unremoved, they can cause immunogenic responses and reduce drug efficacy.
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Application note: The effect of column hardware on the analysis of synthetic oligonucleotides by LC-MS
Therapeutic oligonucleotides represent a recent breakthrough in the pharmaceutical industry.
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Application note: Effect of temperature on single stranded oligonucleotide analysis
Therapeutic oligonucleotides represent a recent breakthrough in the pharmaceutical industry. However, characterisation of oligos, specifically by ion-pair reversed phase liquid chromatography (IPRPLC), can be quite challenging.
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Application note: Effect of perfluorinated alcohols in impurity analysis for synthetic oligonucleotides
Therapeutic oligonucleotides represent a recent breakthrough in the pharmaceutical industry.
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Application note: Effect of alkylamine based Ion-pairing reagents in analysis of siRNA
Silencing RNA, or siRNA, are short, double-stranded RNA molecules which are not only an important research tool in molecular biology, but also an emerging therapeutic modality.
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Application note: Comparison of fully porous and superficially porous particles for the analysis of synthetic oligonucleotides
Superficially porous particle technologies provide a reduced diffusion path in comparison with their fully porous counterparts minimising the resistance to mass transfer during chromatographic separation.
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Coronavirus update: COVID-19 vaccine pre-clinical developments
Drug Target Review rounds up some of the latest news in COVID-19 vaccine candidate R&D.
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Experimental formulation could be future for fast-acting insulin
The novel formulation hit peak activity at nine minutes, less than half the time taken for a commercially available formulation.
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On-demand webinar: Practical considerations for improving high throughput synthesis
Eliminate manual transcription, automate analytical data processing, and make decisions based on data directly linked with high throughput experiments.
webinar
Mobile phase optimisation for oligonucleotide analytical methods by LC-MS
1 July 2020 | By Phenomenex
In this on-demand webinar, we provide an overview of nucleic acid therapeutics and discuss the chromatographic challenges associated with oligonucleotides. We also explore modulation of the mobile phase additives alkylamine ion pair and perfluorinated alcohols. Finally, we will show how optimisation of mobile phase can improve not only chromatographic performance…
