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Biomarkers

 

Biomarkers are a naturally occurring molecule, gene, or characteristic by which a particular disease can be identified.

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Synthetic macrocyclic receptors as tools in drug delivery and drug discovery

10 October 2014 | By ,

Macrocyclic compounds (see Figure 1) have fascinated medicinal chemists for generations. The first ones which have been characterised are the naturally occurring cyclodextrins (CDs), cyclic oligomers of glucose, which can be obtained by bacterial synthesis from starch. Calixarenes (CXs) were among the first man-made macrocycles, followed by crown ethers (Pedersen,…

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AstraZeneca advances tralokinumab to Phase III in severe asthma

14 August 2014 | By AstraZeneca

AstraZeneca announced the start of the Phase III programme for tralokinumab, a potential treatment for patients with severe, inadequately controlled asthma, developed by MedImmune, the company’s global biologics research and development arm...