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Under the microscope: CROs and microplate reader requirements
Contract Research Organisations rely on microplate readers for effective hit discovery. Ian Waddell, of Charles River Laboratories, explains what his needs are.
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Bioinformatics
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Digital 3D brain cell atlas released
The Blue Brain 3D atlas could be the future of analysing all cells in the brain, with high quality, high resolution images that can navigate the brain...
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Application note: Integrated biologics – Enabling high-throughput drug discovery at Amgen with Thermo Fisher™ Platform for Science™ Software
Every day scientists are working to discover and develop new therapies and treatments to change the lives of patients suffering from serious and debilitating illnesses. Amgen Inc. has made it a priority to unlock the potential of biology to discover, develop, manufacture, and deliver innovative therapeutics to patients.
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Application note: Transforming your bioanalysis operations – is a lack of insight slowing you down?
Many bioanalytical labs work with a crowded and siloed set of systems and processes. From part electronic to part paper-based workflows to standalone point-solutions, the result is a lack of insight into data and slower reporting and results handling.
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scRNA-seq technique improves efficiency and accuracy of single cell RNA sequencing
Single nucleotide variations could be the key to better identification of tumour subpopulations...
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Computer simulations predict the spread of HIV
Genetic signatures trace the origin of infection and its potential path through populations, allowing state health departments to track the disease...
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Is acidity the weakness of cancer cells?
Cancer cells proliferating in alkalinity should be more vulnerable in acidic environments, so decreasing the pH may result in decreased proliferation...
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Novel antibiotics can be found on common weeds
The team studied chemical compositions in detail and from one strain of bacteria several antibiotically active chemical substances were discovered...
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New ligand binding site identified through computer simulations
Many therapeutic compounds target GPCRs and so new ligand binding sites can help to design drugs more efficient at targeting GPCR...
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Recessive disorder impairing eyesight has been discovered
Blindness in children has been linked to a recessive genetic disorder caused by the MARK3 gene...
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Tau mutations may increase cancer risk
Mutations in the protein tau, commonly associated with neurodegenerative disorders, may serve as a novel risk factor for cancer...
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Computational methods for drug repositioning
Bioinformatics and computational techniques are now experiencing increased attention as a means of improving the costly and time-consuming drug development process...
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Should LC-MS/MS proteomics guide targeted drug selection for cancer patients?
History has demonstrated that the use of companion in vitro diagnostic tests to select cancer patients positive for a drug target significantly improves response to targeted anti-cancer therapies...
