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ES17 phages can destroy bacteria before gut infection in mice
A study has shown that the ES17 phage binds to heparan sulphate and can target and eliminate ExPEC bacteria in animal models.
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Bacteriophages
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Bacteriophage genes could lead to development of new antibiotics
New research has shown that 'hidden' lysis genes in bacteriophages could be used in the development of a new class of antibiotics.
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Role of retrons in bacteria revealed, with potential for use in gene editing
The role that retrons in bacteria has been discovered by researchers, who found they protect colonies when infected by viruses.
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Platform for hit-to-lead identification of antibacterial lysins developed
A group of scientists has created a novel high-throughput hit-to-lead development platform to identify engineered antibacterial lysins.
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Novel CRISPR enzyme could expand the range of targets for gene therapy
The novel CRISPR-CasΦ enzyme, isolated from bacteriophages, can target a wider range of genetic sequences, say the researchers.
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Empty phage viruses as a method to combat influenza
A group of German researchers has proposed an empty phage capsid with ligands on its surface as a novel technique to treat influenza.
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Novel phage display technique could lead to new peptide-based therapeutics
Researchers have shown that incorporating noncanonical amino acids (ncAAs) in phage display expands the range of peptides it can identify.
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CRISPR-Cas3 used to combat C. difficile in lab and mice
Researchers have shown that CRISPR-Cas3 can successfully attack C. difficile in vitro and in mice, by causing DNA damage to the pathogen.
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Phage-enriched mucosal surfaces could combat bacteria infections
Researchers have found that, in rainbow trout models, phages on mucosal surfaces infect pathogenic bacteria, providing protection.
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Phage therapy shows potential to treat alcoholic liver disease
Researchers have discovered that patients with alcoholic hepatitis had high numbers of a destructive gut bacterium and they were able to use a cocktail of phages to target and kill the bacteria, eradicating the disease.
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Study identifies strain of bacteria as a risk factor for stomach cancer
Researchers have found a specific strain of Helicobacter pylori strongly correlated with stomach cancer...
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Genetically engineered bacteria show promise as a new treatment for constipation
Researchers have genetically engineered bacteria as a potential new treatment for constipation, the finding is significant in part because there are few approved constipation remedies on the market...
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Potential targets for treatment of leishmaniasis identified
Brazilian scientists show that parasite's penetration of host cells increases expression of certain microRNAs capable of inhibiting the action of the immune system...
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University of Leicester gets funding to develop bacteriophages
27 May 2016 | By Victoria White, Digital Content Producer
Professor Martha Clokie has been awarded funding to develop bacteriophages to target bacterial infant diarrhoea in the developing world...
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Pherecydes Pharma appoints Fanneau de La Horie as CEO
22 February 2016 | By Katie Sadler
Pherecydes Pharma has announced the appointment of Guy-Charles Fanneau de La Horie, MBA as its new Chief Executive Officer.