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Application note: Multiplexed detection of mouse cytokines using QBeads and the iQue Screener
This application note illustrates the value of multiplexing, rapid sampling, and assay miniaturisation using QBeads on the iQue Screener...
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Assays
An assay is an analytical procedure in laboratory medicine, pharmacology and molecular biology for measuring the activity of a target entity.
whitepaper
Application note: A high-throughput, radioactivity-free assay for cell-mediated cytotoxicity
In this application note, IntelliCyt Corporation demonstrate a fast, efficient, radioactivity-free CMC assay with low sample input requirements, enabling miniaturisation to 384-well plates, using the iQue® Screener...
webinar
Webinar: Phenotypic assays for CNS disease drug discovery
21 September 2017 | By Charles River Laboratories
In this webinar, we highlight in vitro models and phenotypic assays to discover and validate novel targets and promising lead molecules...
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Application note: Application of MultiCyt QBeads for high throughput cytokine profiling in human peripheral blood mononuclear cells
In this application note IntelliCyt Corporation report on the development and validation of their family of MultiCyt QBeads for the detection of cytokines in a high-throughput screening application on the iQue Screener...
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Expert view: Innovations in 3D
Physiologically relevant models to evaluate the effects of drug candidates early in the drug discovery and development process are becoming increasingly important to develop. Various 3D cell/tissue models have emerged offering relevant environment for ex vivo assays, but significant progress is required to streamline and automate the end-to-end workflow. Several…
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Application note: Characterising chemokine receptor inhibitors with Alpha SureFire Ultra assays
In this application note, PerkinElmer discuss how their ValiScreen CXCR2 GPCR cell line (#ES-145-C) was utilised to examine the downstream effects of chemokine receptor modulation using multiple blocking antibodies and a small molecule...
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Expert view: Effective coupling of assays and cell models
Assay robustness tends to be the favoured descriptor when a particular assay can cope with minute changes in the sample, equipment, or operator. The more robust an assay, the more predictive data it ultimately yields. The industry’s greatest challenge for assay development has always been using those robust assays to…
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Assays In-Depth Focus 2017
This in-depth focus looks at improving assay techniques to produce more detailed results using crystallography. It also covers some aspects of high-content screening assay development that are critical to successful implementation...
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Drug Target Review – Issue #3 2017
Included in this issue: The importance of industry partnerships; Calcilytics as potential novel therapeutic treatments to halt Alzheimer's disease; Accelerating neuroscience research with flow cytometry...
news
New metabolic target in quest to control immune response
Immune cells could help to increase immune activity in vaccines or suppress immune reactions in autoimmune diseases...
news
Blood test for early detection of pancreatic cancer headed to clinic
A newly identified biomarker panel could pave the way to earlier detection and better treatment for pancreatic cancer, according to new research...
article
Phenotypic and target-based screening: complementary or competing?
The screening of drug targets against compound libraries is now a mature and validated approach to identifying the chemical starting points of drugs...
webinar
Cognitive Phenotypes in MS Mouse Models
22 June 2017 | By Charles River Laboratories
40-65% of MS patients have cognitive impairment and touchscreen testing in animal models is a new method to test cognitive issues in MS animal models...
whitepaper
Paper: Acquisition and reversal of visual learning in CVN mice
Peer-reviewed paper on how touchscreen testing is a translational tool to assess cognitive function in a mouse model of Alzheimer’s disease...
