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Vaccine development

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SARS-CoV-2 and immunology: antibody developments

15 February 2021 | By Victoria Rees (Drug Target Review)

Discover the latest in SARS-CoV-2 antibody research as we cover three of the most recent developments in this article.

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Novel DNA-based COVID-19 vaccines induce immune responses in mice

5 February 2021 | By Hannah Balfour (Drug Target Review)

The DREP-S vaccine candidate was found to be the most potent of the two investigational vaccine prototypes, eliciting high titers of SARS-CoV-2 neutralising antibodies after a single dose.

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New COVID-19 vaccine elicits strong protective immunity in mice and monkeys

5 February 2021 | By Victoria Rees (Drug Target Review)

A new MVA-based vaccine has shown success at inducing COVID-19 antibody and T-cell responses in pre-clinical studies.

Coronavirus particle being injected by a syringe labelled 'Covid-19 Vaccine'

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COVID-19 vaccine candidate stimulates neutralising antibody production in vivo

3 February 2021 | By Hannah Balfour (Drug Target Review)

The novel haptenised SARS-CoV-2 s-Spike vaccine, BVX-0320, stimulated mice to create neutralising antibodies that were able to reduce SARS-CoV-2 plaques in a neutralisation test.

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New method for rapid development of vaccines for pre-clinical tests

19 January 2021 | By Victoria Rees (Drug Target Review)

Using synthetic chemistry, researchers have fused hydrophobic adjuvants with water-soluble proteins to create a new type of vaccine.

blur viral particle surrounded by antibodies

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Artificial intelligence analyses how viruses evade the immune system

15 January 2021 | By Hannah Balfour (Drug Target Review)

The natural language processing model trained using viral protein sequence data was able to predict promising targets for vaccines against HIV, influenza and coronaviruses.

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Nanoparticle vaccine could protect against multiple coronaviruses

13 January 2021 | By Victoria Rees (Drug Target Review)

A new protein-based nanoparticle vaccine protected mice against a variety of coronaviruses, researchers have shown.

mouse in laboratory with paws on scientist's gloved hand

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Inhaled vaccine induces strong immune response in animal models

11 December 2020 | By Hannah Balfour (Drug Target Review)

Scientists report their phage-based inhaled vaccine delivery system elicited a robust antibody response in both mice and non-human primates.

SARS-CoV-2 particle in grey surrounded by various blue and green antibodies all on a red background

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Triggering an IgA response could increase COVID-19 vaccine efficacy

8 December 2020 | By Hannah Balfour (Drug Target Review)

Two new studies suggest that SARS-CoV-2-specific IgA antibodies are more neutralising and therefore COVID-19 vaccines should encourage an IgA response.

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COVID-19 vaccine candidate is 96.4 percent effective in mice, study shows

1 December 2020 | By Victoria Rees (Drug Target Review)

Administering two doses of a COVID-19 vaccine called BVX-0320 is effective in mouse models, a pre-clinical study has shown.

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Tweaking synonymous sites for gene therapy and vaccines

30 November 2020 | By Professor Laurence D Hurst (University of Bath)

Professor Laurence D Hurst explains why understanding the nucleotide mutations in viruses, including SARS-CoV-2, can have significant implications for vaccine design.

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SARS-CoV-2 mutations do not increase transmissibility, research shows

30 November 2020 | By Victoria Rees (Drug Target Review)

Having analysed the SARS-CoV-2 genomes from over 46,723 patients, researchers have found no mutations that increase transmissibility.

Black and red capsules in a pile with top one labelled 'COVID-19' in white writing - idea of a tablet/pill COVVID-19 vaccine

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COVID-19 vaccine tablet significantly reduces viral load in hamsters

17 November 2020 | By Hannah Balfour (Drug Target Review)

Hamster challenge study results suggests the oral COVID-19 vaccine induces a robust immune response, protecting the animals from infection.

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Study reveals roles of antibodies in SARS-CoV-2 disease severity

15 October 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that the level of antibodies in the serum of SARS-CoV-2 patients correlated with disease severity.

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COVID-19 vaccines should not be affected by SARS-CoV-2 mutations, researchers say

12 October 2020 | By Victoria Rees (Drug Target Review)

A common SARS-CoV-2 mutation known as D614G should not impact on the efficacy of COVID-19 vaccines, a study has shown.

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Vaccine development