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Imaging, sequencing & screening

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Over 200 molecules and genes linked to COVID-19 severity

14 October 2020 | By Victoria Rees (Drug Target Review)

A team has identified 219 molecules and genes that influence the severity of COVID-19 in patients, providing information that could aid the development of therapeutics.

news

COVID-19 vaccines should not be affected by SARS-CoV-2 mutations, researchers say

12 October 2020 | By Victoria Rees (Drug Target Review)

A common SARS-CoV-2 mutation known as D614G should not impact on the efficacy of COVID-19 vaccines, a study has shown.

purpley-blue antibodies surrounding a red and black SARS-CoV-2 viral particle

news

SARS-CoV-2-targeting antibodies persist for at least three months in COVID-19 patients

9 October 2020 | By Hannah Balfour (Drug Target Review)

Two separate studies show that IgG serotype antibodies targeting the SARS-CoV-2 spike protein are still detectable in patient’s blood and saliva after 90 days.

news

SARS-CoV-2 mechanism of infection revealed using cryo-electron microscopy

8 October 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that the surface of SARS-CoV-2 can take on at least 10 different structural states when in contact with ACE2.

SARS-CoV-2 - COVID-19 - inhibition by LY6E

news

Team identifies T-cell epitopes to inform COVID-19 vaccine development

2 October 2020 | By Victoria Rees (Drug Target Review)

Researchers studied 180 convalescent COVID-19 patients to reveal T-cell epitopes that they say can be targeted by a vaccine.

news

Study reveals 10 SARS-CoV-2 epitopes that could be targeted by antibodies

30 September 2020 | By Victoria Rees (Drug Target Review)

An analysis of SARS-CoV-2 has allowed researchers to identify epitopes recognised by a large fraction of COVID-19 patients, with 10 that could be targeted by antibodies.

cartoon of magnifying glasses over covid-19 particles in lungs

news

Why do some patients develop COVID-19 pneumonia?

28 September 2020 | By Hannah Balfour (Drug Target Review)

Scientists reveal that some patients who develop severe COVID-19 symptoms mount ineffective immune responses due to a lack of type I interferons, either through genetic mutation or inactivation by auto-reactive antibodies.

news

Interactive 3D model of SARS-CoV-2 surface released

25 September 2020 | By Victoria Rees (Drug Target Review)

A new interactive map of the surface of SARS-CoV-2, featuring the Spike, Envelope and Membrane proteins, has been released for researchers to use.

news

Team reveals why children’s immune response to COVID-19 is better than adults’

24 September 2020 | By Victoria Rees (Drug Target Review)

Researchers have identified two molecules that explain why children experience COVID-19 differently to adults.

news

Researchers discover druggable pocket on SARS-CoV-2 Spike protein

22 September 2020 | By Victoria Rees (Drug Target Review)

A pocket in the SARS-CoV-2 Spike protein has been discovered by researchers, who say it could be a drug target for COVID-19.

news

Novel pseudo-virion probes to study SARS-CoV-2 viral entry

18 September 2020 | By Hannah Balfour (Drug Target Review)

The non-infectious quantum dot probes are designed to enable researchers to safely study interactions between the SARS-CoV-2 Spike (S) protein and human cells.

news

Drug target to combat three coronavirus diseases identified by researchers

16 September 2020 | By Victoria Rees (Drug Target Review)

Researchers studying the PLpro binding site of three coronaviruses, including SARS-CoV-2, say the BL2 loop could be targeted by antiviral drugs.

article

Understanding the limits of synthetic biology through the origins of SARS-CoV-2

15 September 2020 | By Marc Baiget Francesch (International Journal of Molecular Sciences)

Conspiracy theories about COVID-19 have been spreading since the early days of the outbreak. But how do we know whether a biological entity is artificially made or has occurred naturally? Marc Baiget Francesch explores the capabilities of current scientific approaches in terms of virus engineering and how this applies to…

news

Tool to track SARS-CoV-2 mutations could inform drug development

11 September 2020 | By Victoria Rees (Drug Target Review)

A new tool called COVID-3D that monitors SARS-CoV-2 genome mutations could aid drug and vaccine development, its creators say.

news

Researchers capture images of cells infected with SARS-CoV-2

11 September 2020 | By Victoria Rees (Drug Target Review)

Using scanning electron microscopy, researchers have captured images of epithelial cell cultures infected by SARS-CoV-2.

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Imaging, sequencing & screening