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Computational approach identifies novel COVID-19 vaccine targets
Researchers used computational tools to identify regions of the SARS-CoV-2 virus that could potentially provide a safe and long-term immune response.
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Drug targets
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Researchers find microglia are key to protecting brain from viral infection
The team found microglia and CD8 T cells were vital to protecting neurons from vesicular stomatitis virus (VSV) infection and suggest loss of taste and smell in COVID-19 could be due to a certain mechanism of infection.
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Investigational anti-SARS-CoV-2 molecules show efficacy in pre-clinical studies
Pre-clinical testing of the COVIDTRAP™ (STI-4398) protein and STI-1499 antibody reveal they can inhibit SARS-CoV-2 from infecting cells.
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The effect of temperature and humidity on the number of cases and deaths of COVID-19 all over the world
Sarah Ahmed explores how environmental factors may be causing the disparity in numbers of cases between different countries.
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Researchers identify 27 biomarkers of COVID-19 disease severity
Mass spectrometry revealed biomarkers that could be used as drug targets for developing novel therapeutics or to predict whether a patient with COVID-19 will become severely ill.
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Mapping SARS-CoV-2 infection in the airway
Researchers found there is a gradient of SARS-CoV-2 infectivity down the airway and that the severe pneumonia symptoms may be caused by aspiration of oral contents into the lungs.
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Using scientific literature to aid the development of a safe and effective COVID-19 vaccine
Researchers in the US describe how they utilised previously published scientific literature to guide the design of their potential COVID-19 vaccine.
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SARS-CoV-2 mouse model recapitulates human infection
Researchers develop a knock-in mouse expressing human angiotensin-converting enzyme 2 (hACE2) to model SARS-CoV-2 infection for research and therapeutic or vaccine testing.
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Chemical formulas relevant to COVID-19 drug targets
Find several chemical formulas for potential COVID-19 therapeutics and drug targets currently in development here.
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Blood test could identify those most at risk from COVID-19
Collaborative research has revealed two hallmarks of COVID-19 infection associated with more severe symptoms that can be identified by a blood test.
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Human enzymes could be driving COVID-19 evolution, suggest researchers
Post-infection genome editing could be the cause of mutations in the SARS-CoV-2 virus responsible for the COVID-19 pandemic, driving its evolution.
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Antibody named S309 from SARS patient shows promise against COVID-19
An antibody called S309, identified in a blood sample from a SARS patient, inhibits related coronaviruses, including SARS-CoV-2, researchers have found.
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Study finds coronaviruses do not readily induce cross-protective antibody responses
Researchers have found that antibodies produced in response to SARS and COVID-19 are cross-reactive, but not cross protective in cells and mice.
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Lipid mediators suggested as potential COVID-19 inflammation treatment
A new article has outlined the body's inflammatory response to COVID-19 infection, saying that lipid mediators derived from omega-3 fatty acids could prevent life-threatening inflammation.
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Can a computer help us find a treatment for COVID-19?
Researchers are utilising computers to aid in their investigations into a COVID-19 treatment. Here, we highlight three studies using simulations, calculations and AI to identify a drug to combat the coronavirus.
