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Nanobodies developed to image COVID-19 Spike protein

20 April 2020 | By Victoria Rees (Drug Target Review)

Researchers in the UK have selected nanobodies that bind with high affinity to the Spike protein on the COVID-19 coronavirus, enabling stabilisation for imaging.

news

Severe COVID-19 symptoms may be caused by overactive neutrophils

16 April 2020 | By Hannah Balfour (Drug Target Review)

An international consortium suggest that the severe symptoms of COVID-19, including Acute Respiratory Distress Syndrome (ARDS), could be caused by Neutrophil Extracellular Traps (NETs).

article

The coronavirus as a personalised enemy of mankind

15 April 2020 | By Dr Ulrich Kutschera (University of Kassel)

How has evolution led us to the point where humans are an ideal host for SARS-CoV-2, the virus that causes the COVID-19 coronavirus?

article

Gender-specific coronavirus infections in the light of evolution

9 April 2020 | By Dr Ulrich Kutschera (University of Kassel)

Dr Kutschera discusses the differences between males and females in relation to infection from the COVID-19 coronavirus.

artist impression of the anatomy of the lungs with bronchi and bronchioles highlighted in red

news

Human lung epithelium model being tested as a platform for COVID-19 research

9 April 2020 | By Hannah Balfour (Drug Target Review)

The developers of the lung epithelium model plan to investigate whether SARS-CoV-2 can infect and replicate in the model to assess whether it could be used in the fight against COVID-19.

news

Scientists identify fusion peptide as promising COVID-19 drug target

8 April 2020 | By Hannah Balfour (Drug Target Review)

Researchers working on related coronaviruses SARS and MERS have identified the membrane fusion peptide on the Spike protein as a possible drug target for SARS-CoV-2, the virus causing COVID-19.

news

Receptors enabling COVID-19 infection found on cilia progenitor cells, study shows

8 April 2020 | By Victoria Rees (Drug Target Review)

Sequencing almost 60,000 cells, researchers have found that certain cilia progenitor cells have gene transcripts for ACE2 and co-factor TMPRSS2, enabling COVID-19 infection.

news

Researchers reveal how SARS antibody binds to COVID-19 coronavirus

7 April 2020 | By Victoria Rees (Drug Target Review)

The interaction between a SARS antibody called CR3022 and the COVID-19 coronavirus has been mapped by researchers, revealing a viral vulnerability.

news

Celltrion to select lead antibody candidates to fight COVID-19

6 April 2020 | By Victoria Rees (Drug Target Review)

Following the screening of antibodies, Celltrion will now identify the most potent out of 300 hits that work against the COVID-19 coronavirus best.

news

Decoy ACE2 receptors could be promising COVID-19 infection-preventing drug

3 April 2020 | By Hannah Balfour (Drug Target Review)

Recombinant angiotensin converting enzymes (ACE2) reduced infection and viral growth in cell cultures and organoids by acting as a decoy for SARS-CoV-2.

researcher in lab coat touching drug design icon

news

Free access to AI Clinical Research Navigator tool for COVID-19 researchers

1 April 2020 | By Hannah Balfour (Drug Target Review)

In light of the COVID-19 pandemic, the creators of the Clinical Research Navigator (CRN) tool have offered free access to their system for biomedical researchers.

face mask, white tablets and syringe of medication

news

Nafamostat inhibits SARS-CoV-2 infection, preventing COVID-19 transmission

31 March 2020 | By Hannah Balfour (Drug Target Review)

Researchers have demonstrated that Nafamostat mesylate (Fusan) can inhibit SARS-CoV-2 Spike protein-initiated membrane fusion at concentrations likely achievable and safe in patients.

article

Host pathways in coronavirus replication and COVID-19 pre-clinical drug target identification using proteomic and chemoinformatic analysis

30 March 2020 | By Joseph Steward (Moores Cancer Center)

The identification of host dependency factors mediating virus infection may provide key insights into effective molecular targets for developing broadly acting antiviral therapeutics against SARS-CoV-2 and other deadly coronavirus strains. Here, Joseph Steward highlights key findings of recent research.

outlines of coronavirus particles in white on a red background

news

Remdesivir most promising COVID-19 drug, say researchers

27 March 2020 | By Hannah Balfour (Drug Target Review)

A review of potential COVID-19 therapeutics revealed that the most effective are likely to be those directly targeting SARS-CoV-2, such as remdesivir and tilarone.

news

Collaboration initiated to develop COVID-19 immunotherapy

26 March 2020 | By Victoria Rees (Drug Target Review)

The University of Georgia and CEL-SCI Corporation have partnered to develop an immunotherapy to combat the COVID-19 coronavirus using the Ligand Antigen Epitope Presentation System (LEAPS) technology.

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