Vladimir Silnikov

Inhibition of RNA-containing viruses by artificial RNases

The toxicity and antiviral properties of 24 low-molecular-weight artificial RNases…

16 June 2016 | By Dmitry Klinov (Federal Medical and Biological Agency of the Russian Federation), Elena Isaeva (D. I. Ivanovsky Institute of Virology), Ludmila Koroleva (Siberian branch of the Russian Academy of Sciences), Olga Morozova (D. I. Ivanovsky Institute of Virology and Federal Medical and Biological Agency of the Russian Federation), Vladimir Silnikov (Siberian branch of the Russian Academy of Sciences)

The toxicity and antiviral properties of 24 low-molecular-weight artificial RNases (artRNases) including peptides, peptidomimetics, N-alkyl-substituted 1,4-diazabicyclo[2.2.2]octane (DABCO) and a silver (I) complex with cystine were analysed for viruses containing single-stranded and double-stranded genomic RNA (the tick-borne encephalitis virus; TBEV and the influenza virus, respectively) in vitro and in vivo by…