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Washington University School of Medicine

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Drugs that trigger immune system alarm could lead to new HIV therapies

5 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have suggested that dormant HIV can be eradicated from cells by attacking it based on its viral activities.

news

Researchers find TMPRSS2 and TMPRSS4 enable SARS-CoV-2 infection of digestive system

14 May 2020 | By Victoria Rees (Drug Target Review)

A group of researchers has found that SARS-CoV-2 may not spread by faecal-to-oral transmission, but is able to infect the gastrointestinal tract via the TMPRSS2 and TMPRSS4 enzymes.

news

Silencing RNA nanotherapy shows promise in treating pancreatic cancer

22 October 2019 | By Rachael Harper (Drug Target Review)

Peptide-based nanoparticles have been designed which can suppress pancreatic cancer growth without the toxic side effects.

news

Microglia critical for neurodegeneration in mice, study finds

14 October 2019 | By Victoria Rees (Drug Target Review)

Microglia brain immune cells are vital in conjunction with the APOE4 gene during the development of Alzheimer’s in mouse models, researchers have found.

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Genes linked to Alzheimer’s risk have been identified

15 August 2019 | By Nic Losardo (Drug Target Review)

Two genes that influence risk Alzheimer's disease could provide scientists with new targets for delaying the onset of the condition's symptoms.

news

Neurofilament light chains detect Alzheimer’s damage before symptoms

22 January 2019 | By Drug Target Review

A simple blood test reliably detects signs of brain damage in people on the path to developing Alzheimer's disease...

news

Stem cell’s could produce insulin to treat diabetes

18 January 2019 | By Drug Target Review

Researchers have transformed stem cells into cells that are able to produce insulin - the hormone that produces blood sugar...

news

MRI scans shows promise in predicting dementia

23 November 2018 | By Drug Target Review

Brain changes evident in scans before memory, cognitive decline...

news

Biodegradable devices speed up nerve regeneration

9 October 2018 | By Drug Target Review

Researchers have developed an implantable and biodegradable device to aid the regeneration of nerve after damage from accidents and sports injuries...

news

Psoriasis treated with compound derived from immune cells

19 April 2018 | By Dr Zara Kassam (Drug Target Review)

A compound may be effective against other autoimmune diseases, mouse study shows...

news

Macular degeneration linked to ageing immune cells

9 April 2018 | By Dr Zara Kassam (Drug Target Review)

Older cells promote inflammation, abnormal blood vessel growth that can lead to blindness...

news

TREM2 gene mutation poses both risk and benefits in Alzheimer’s disease

9 October 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have identified that a mutation in the gene TREM2, can substantially raise a person’s risk of Alzheimer’s disease...

news

Blocking ApoE4 may prevent nerve cell death in Alzheimer’s disease

21 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified that the presence of ApoE4 exacerbates the brain damage caused by toxic tangles of tau protein...

news

Zika virus kills brain cancer stem cells

5 September 2017 | By Dr Zara Kassam (Drug Target Review)

New research shows that the Zika virus kills brain cancer stem cells...

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Washington University School of Medicine