article The Editors’ views: Drug Target Review’s 2020 round-up 14 December 2020 | By Hannah Balfour (Drug Target Review), Victoria Rees (Drug Target Review) The Junior Editors of Drug Target Review, Victoria Rees and Hannah Balfour, discuss some of the most noteworthy news and announcements from this year.
news Lysosomes key to coronavirus shedding, finds study 29 October 2020 | By Hannah Balfour (Drug Target Review) Scientists reveal that coronaviruses de-activate lysosomes before using them to exit infected cells and spread through the body.
news NIH to support 85 highly innovative research projects 7 October 2020 | By Hannah Balfour (Drug Target Review) The US National Institutes of Health (NIH) will award a total of $251 million over five years to 85 high-risk, high-reward biomedical or behavioural research projects.
news 2020 Nobel Prize goes to discoverers of hepatitis C 6 October 2020 | By Hannah Balfour (Drug Target Review) The 2020 Nobel Prize in Physiology or Medicine has been bestowed upon researchers who helped identify the hepatitis C virus in the 1970s.
news Researchers map pathoconnectome of eye disease and retinal circuitry 30 September 2020 | By Victoria Rees (Drug Target Review) Scientists have produced the first pathoconnectome - an open access map for other researchers that shows how eye disease can alter retinal circuitry.
news New set of channels between malaria parasite and blood cells discovered 3 August 2020 | By Victoria Rees (Drug Target Review) A team has discovered channels that enable the transport of lipids between the malaria parasite and red blood cells during infection.
news New insights into human and mouse genomes published in NIH study 30 July 2020 | By Victoria Rees (Drug Target Review) The third phase of the ENCODE project has been released, with new information on genes and their potential regulators in their respective genomes.
article Five of the most recent microscopy developments 23 July 2020 | By Victoria Rees (Drug Target Review) Drug Target Review highlights five of the latest imaging advancements in the field of microscopy.
news Novel compound could treat type 2 diabetes without common side effects 24 June 2020 | By Victoria Rees (Drug Target Review) Two molecules combined into a new substance to treat type 2 diabetes lowered blood sugar in shrew models without causing nausea, vomiting and weight loss.
news CD47 blockade could work as immunotherapy across multiple diseases 24 June 2020 | By Victoria Rees (Drug Target Review) Researchers have demonstrated that blocking CD47-mediated signalling in mice can enhance the speed of pathogen clearance, presenting a new potential form of immunotherapy.
news Potential for Mycoplasma pneumoniae vaccine through lipoprotein removal, finds study 18 June 2020 | By Victoria Rees (Drug Target Review) A new study has shown that effective and safe M. pneumoniae vaccine could be possible by removing certain lipoproteins from the bacteria.
news Researchers find microglia are key to protecting brain from viral infection 8 June 2020 | By Hannah Balfour (Drug Target Review) The team found microglia and CD8 T cells were vital to protecting neurons from vesicular stomatitis virus (VSV) infection and suggest loss of taste and smell in COVID-19 could be due to a certain mechanism of infection.
news 3D map of the heart’s intracardiac nervous system (ICN) revealed 4 June 2020 | By Hannah Balfour (Drug Target Review) The 3D map, created using Knife-Edge Scanning Microscopy and analysed using laser capture microdissection, reveals new insights about the nervous control of the heart.
news Mapping SARS-CoV-2 infection in the airway 2 June 2020 | By Hannah Balfour (Drug Target Review) Researchers found there is a gradient of SARS-CoV-2 infectivity down the airway and that the severe pneumonia symptoms may be caused by aspiration of oral contents into the lungs.
news Oxford University and NIH COVID-19 vaccine shows success in rhesus macaques 18 May 2020 | By Victoria Rees (Drug Target Review) A vaccine currently in Phase I clinical trials was effective at inducing immune responses against SARS-CoV-2 in mice and rhesus macaques.
