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US Food and Drug Administration (FDA)

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Unpredicted binding found between SARS-CoV-2 and hepatitis C drug, telaprevir

24 March 2021 | By Victoria Rees (Drug Target Review)

Insights into the interaction between telaprevir and the SARS-CoV-2 main protease could aid in future COVID-19 drug design, say scientists.

news

AI-based method used to screen for Alzheimer’s disease drugs

5 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have used artificial intelligence to screen 80 FDA-approved drugs and reveal which could be used as Alzheimer's treatments.

article

Advancing neutralising antibody therapies for COVID-19

17 February 2021 | By Hannah Balfour (Drug Target Review)

In this article, Ian Chan, Chief Executive Officer and Co-Founder of biotech company Abpro, discusses the development of neutralising antibodies for SARS-CoV-2. Abpro’s neutralising antibody candidate ABP 300 is currently in Phase II/III trials.

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New small molecules can prevent filovirus infection in cells

9 February 2021 | By Victoria Rees (Drug Target Review)

Through a series of experiments, researchers have identified small drug molecules that can inhibit filoviruses such as Ebola and Marburg.

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Researchers identify how Zika infects foetuses and a potential drug to prevent it

4 February 2021 | By Hannah Balfour (Drug Target Review)

According to scientists, maternal cells act as a reservoir for Zika, enabling the virus to pass from mother to foetus during pregnancy.

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HIV drugs could be repurposed to prevent the onset of macular degeneration

2 February 2021 | By Hannah Balfour (Drug Target Review)

Analysis reveals people taking nucleoside reverse transcriptase inhibitors are significantly less likely to develop dry macular degeneration, a leading cause of age-related vision loss.

Coronavirus particles in green with purple extracellular proteins

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N439K variant of SARS-CoV-2 is resistant to some neutralising antibodies, shows study

1 February 2021 | By Hannah Balfour (Drug Target Review)

The N439K mutation improves the interaction between SARS-CoV-2 Spike protein and the viral receptor ACE2 and eludes antibody-mediated immunity, say investigators.

white antibodies attacking an orange coronavirus particle with yellow neuraminidase proteins on its surface

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Novel antibody candidate could offer pan-coronavirus protection

26 January 2021 | By Hannah Balfour (Drug Target Review)

The lead candidate, ADG2, was able to neutralise SARS-CoV and various strains of SARS-CoV-2, including those that are resistant to currently available antibody treatments.

Bees laying red propolis at the edges of their hive. The propolis resin protects the hive from bacteria and fungus.

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Red propolis could be a better treatment for schistosomiasis

8 December 2020 | By Hannah Balfour (Drug Target Review)

Investigators found that red propolis can kill schistosomes at all stages of development and therefore suggest it could be highly effective for treating schistosomiasis.

silver T lymphocytes (cells) on a light blue to white gradient background

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A novel CAR T-cell therapy for type 1 diabetes

4 December 2020 | By Hannah Balfour (Drug Target Review)

Researchers show how genetically engineered five-module chimeric antigen receptor (5MCAR) T cells can be directed to destroy T cells causing autoimmune diseases.

article

Tracking SARS-CoV-2 with genome sequencing

2 December 2020 | By Nikki Withers (Drug Target Review)

Researchers have been tracking SARS-CoV-2 by sequencing the genomes of virus samples collected from diagnostic testing. They hope that using next-generation sequencing (NGS) on SARS-CoV-2 will help to accurately diagnose the novel coronavirus, identify mutations and track its history. This article explores the findings of their latest study and what…

article

Biosynthetic polysaccharide-based drugs and nutraceuticals from non-animal sources

2 December 2020 | By Payel Datta (Rensselaer Polytechnic Institute), Robert J Linhardt (Rensselaer Polytechnic Institute)

Glycosaminoglycans (GAGs) are a class of naturally occurring polysaccharides that play vital roles in cellular functions. GAGs (eg, hyaluronic acid, heparosan, chondroitin, chondroitin sulfate, heparan sulfate and heparin) have also been utilised in biopharmaceutical and nutraceutical industries. Animal-sourced GAGs can contain process impurities and contaminants, which may result in adverse…

cartoon of a blood vessel with coronavirus particles attached to the lining of the vessel and a blood clot formed of red and white blood cells

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Autoantibodies and over-active neutrophils may be cause of COVID-19 blood clots

3 November 2020 | By Hannah Balfour (Drug Target Review)

According to a new study, blood clots in patients with severe COVID-19 are caused by an autoimmune antibody that circulates in the blood and attacks cells.

Syringe drawing liquid from a vial labelled 'REMDESIVIR', on a background of abstract SARS-CoV-2 particles [Credit: ffikretow@hotmail.com / Shutterstock.com].

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Researchers identify a potential remdesivir resistance mechanism in SARS-CoV-2

8 October 2020 | By Hannah Balfour (Drug Target Review)

Exploring how the Ebola virus develops remdesivir resistance has highlighted a mutation that could allow SARS-CoV-2 to do the same.

SARS-CoV-2 viral particle in crosshares with words 'target locked' above

news

Experimental antiviral AR-12 could be a promising COVID-19 treatment

23 September 2020 | By Hannah Balfour (Drug Target Review)

Scientists have demonstrated that AR-12 can inhibit SARS-CoV-2 replication and are working to initiate clinical trials evaluating the antiviral drug.

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US Food and Drug Administration (FDA)