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AI method reveals 17 existing drugs that may fight against COVID-19

24 August 2021 | By Anna Begley (Drug Target Review)

Scientists used artificial intelligence to identify 17 existing drugs that could kill SARS-CoV-2 in cells, including a dietary supplement.

news

New technique developed for identifying therapeutic nanobodies

25 June 2021 | By Victoria Rees (Drug Target Review)

Researchers have used a new method for discovering nanobodies to identify potential therapeutics against SARS-CoV-2 infection.

news

Algorithm created to analyse large single-cell sequencing datasets

20 April 2021 | By Victoria Rees (Drug Target Review)

An algorithm which continuously processes new data has been developed to allow researchers to access and analyse single-cell sequencing information.

news

Inhibiting IRE1α pathway could be novel therapeutic strategy for lupus

29 March 2021 | By Victoria Rees (Drug Target Review)

A study has revealed that blocking a molecule called IRE1α could prevent the release of neutrophil extracellular traps in lupus pathogenesis.

news

Bioactive compound in ginger could be used in treatment of lupus

7 January 2021 | By Victoria Rees (Drug Target Review)

According to new research, the bioactive compound of ginger root, 6-gingerol, prevented disease progression of lupus in mice.

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Rod-shaped microparticles could improve immune system response to COVID-19

11 June 2020 | By Victoria Rees (Drug Target Review)

Researchers have suggested that neutrophils, which contribute to the development of ARDS in COVID-19 patients, could be diverted from the lungs by rod-shaped particles in a new form of treatment.

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Investigational drug kills pancreatic cells in mice by cutting off cysteine supply

3 April 2020 | By Victoria Rees (Drug Target Review)

Researchers have demonstrated that cysteinase, a new drug compound, can starve pancreatic cells of cysteine supply, causing ferroptosis.

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Artificial enzyme catalytic capabilities improved, say researchers

11 March 2020 | By Victoria Rees (Drug Target Review)

A study has shown that using a particular three-stranded structure can extend the catalytic performance of artificial metalloenzymes.

Faster-drug-discovery-to-hit-'undruggable'-targets

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Faster drug discovery could hit ‘undruggable’ targets

23 January 2020 | By Rachael Harper (Drug Target Review)

A new technique has been developed which has the potential to harness bacteria to produce billions of different drug candidates to treat diseases like cancer.

news

Industry collaborate to screen existing drugs to repurpose for cystic fibrosis

17 January 2020 | By Drug Target Review

In an effort to address some of the more serious untreatable infections encountered by patients with cystic fibrosis, Calibr will collaborate with the Cystic Fibrosis Foundation on a two-year project.

article

Getting precise: how humanised models aid in biologics drug discovery

17 December 2019 | By Paul Volden (Taconic Biosciences)

Humanised immune system (HIS) models have enabled numerous in vivo evaluations of immuno-modulating biologic drugs and ongoing improvements continue to extend their utility. Paul Volden explores the application of HIS models in precision and personalised medicine with a focus on biologics, including how HIS models are used, why they are…

news

New technique enables detailed genetic analysis of cancer cells

16 May 2019 | By Drug Target Review

A new way to cleanly separate out cancer cells from a blood sample will enable comprehensive genetic profiling of the cancer cells.

news

New DNA ‘shredder’ technique goes beyond CRISPR’s scissors

9 April 2019 | By Drug Target Review

A new CRISPR-based tool that acts more like a shredder is able to wipe out long stretches of DNA in human cells with programmable targeting...

news

Non-invasive imaging for small airway lung disease

14 March 2019 | By Iqra Farooq (Drug Target Review)

A non-invasive method of imaging tiny bronchioles in the lungs of chronic obstructive pulmonary disease means patients could detect the disease earlier...

news

Live-imaging technique reveals cellular plug for leaky bio barrier

15 February 2019 | By Drug Target Review

A microscopy assay has shown the repair mechanism involved in the activation of a protein called Rho, used to plug leaky biological barriers in the body...

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