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University of California Los Angeles (UCLA)

Investigating neural oscillations in human brain organoids

21 September 2021 | By Anna Begley (Drug Target Review)

This article delves into research at the University of California Los Angeles, US, where stem-cell derived brain organoids that can mimic electrical activity have been developed.

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Removal of RNA-binding protein improves leukaemia survival

30 July 2021 | By Anna Begley (Drug Target Review)

Study shows that removing the protein IGF2BP3 slows cancer growth and increases chances of survival of rare types of leukaemia in mice.

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Common antidepressant drugs fight cancer in mice, study shows

11 June 2021 | By Victoria Rees (Drug Target Review)

Monoamine oxidase inhibitors can block the function of a protein, helping T cells to effectively fight cancer, a study in mice has shown.

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Stem cell therapy repairs damage from dementia in mouse brains

22 April 2021 | By Victoria Rees (Drug Target Review)

Researchers have developed a stem cell therapy that could treat the damage caused by dementia by launching a repair response.

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Deactivating gene could boost immunotherapy for head and neck cancer

24 March 2021 | By Victoria Rees (Drug Target Review)

Inhibiting the KDM4A enzyme slowed the growth of head and neck cancer in mouse models, also demonstrating promise to aid immunotherapy.

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Chemical cocktail creates new avenues for generating muscle stem cells

22 March 2021 | By Victoria Rees (Drug Target Review)

A combination of chemicals has shown promise in pre-clinical studies to produce muscle stem cells, giving hope for regenerative medicine.

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Myc gene linked to alternative splicing changes in several cancers

18 February 2020 | By Mandy Parrett (Drug Target Review)

A collaboration of academic institutions in the United States has identified a gene that is linked to alternative splicing changes that occur in several cancers.

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Accurate model of organ scarring created using stem cells in a lab

16 December 2019 | By Rachael Harper (Drug Target Review)

Researchers have developed a 'scar in a dish' model derived from human stem cells which mimics the progressive scarring that occurs in human organs and has lead to a drug candidate being identified to stop the progression of fibrosis.

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Novel metabolic-focused high-throughput screening method developed

19 November 2019 | By Victoria Rees (Drug Target Review)

Researchers have created a new high-throughput screening system which could identify new drugs by focusing on nucleotide metabolism.

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Drug repurposing using off patent drugs as antifungals

9 November 2018 | By Iqra Farooq (Drug Target Review)

Researchers have identified that Alexidine dihydrochloride can be used as a broad spectrum antifungal, and can also kill biofilms formed by these fungi...

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Study uses brain cells in a dish to understand polygenic origins of schizophrenia

18 October 2018 | By Drug Target Review

Using a unique in vitro method, scientists in California have made inroads into understanding the mechanics of the polygenic origins of schizophrenia...

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Scientists discover over 7,000 effective antibiotic combinations

3 September 2018 | By Iqra Farooq (Drug Target Review)

Researchers discovered effective antibiotic combinations using four or five drugs, despite claims that combinations of three or more won't work...

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Cambinol halts spread of toxic protein associated with Alzheimer’s progression

8 May 2018 | By Dr Zara Kassam (Drug Target Review)

Research could help lead to the design of drugs that slow neurodegeneration...

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New method allows scientists to watch brain cells interacting in real time

6 April 2018 | By Drug Target Review

Findings could deepen understanding of neurological disorders...

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PSMA PET/CT imaging provides precision radiation therapy for prostate cancer

2 February 2018 | By Dr Zara Kassam (Drug Target Review)

A nuclear medicine scan may locate prostate cancer recurrence after radical prostatectomy early after disease recurrence and could help guide salvage radiotherapy...

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University of California Los Angeles (UCLA)