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Controlling PTEN gene could combat paediatric rhabdomyosarcoma
The decreased expression of PTEN in mouse models was found to make rhabdomyosarcoma tumours more aggressive, highlighting new treatment approaches.
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Metabolic pathway could potentially enhance vaccine effectiveness
A metabolic control pathway that regulates T follicular helper cells could enhance vaccine effectiveness, including those that protect against COVID-19.
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Blocking Treg pathway sensitises mice to immunotherapy
Researchers have shown that inhibiting Treg activation in tumours can provide effective immune responses without autoimmune toxicity.
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Potential strategy to treat COVID-19-related cytokine storms identified
Researchers have found that neutralising antibodies for the TNF-alpha and IFN-gamma cytokines can prevent death from SARS-CoV-2 in mice.
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ABCC4 transporter could be a novel target for paediatric medulloblastoma treatments
Researchers demonstrated that ABCC4 is essential to signalling in the SHH subgroup of medulloblastomas and when expression was reduced in mice, the tumours shrank.
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Inflammatory regulator molecule identified by study
Researchers have discovered an enzyme that is pivotal in deciding whether cells survive or die in inflammatory diseases, so provides a drug target.
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Kenpaullone protects from cisplatin-induced hearing loss
Researchers have discovered that inhibiting an enzyme called cyclin-dependent kinase 2 protects mice and rats from noise- or drug-induced hearing loss...
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Sonic Hedgehog pathway identified as a target against medulloblastoma
Researchers raise hopes for developing a combination targeted therapy to treat medulloblastoma and other tumours...
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Antibiotic identified that reduces infection risk in young leukaemia patients
Researchers have identified an antibiotic that significantly reduced the odds of infections in children starting treatment for ALL without an apparent increase in antibiotic resistance...
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Researchers identify a key controller of biological machinery in cell’s ‘antenna’
St. Jude Children’s Research Hospital discovery of a regulatory enzyme working at the primary cilium could lead to treatments for the brain tumour medulloblastoma.
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Scientists reveal how signals from pathogenic bacteria reach danger sensors of cells
29 September 2016 | By Niamh Louise Marriott, Digital Content Producer
Signals from infectious bacteria gain entry into the cytoplasm of host cells to activate disease-fighting inflammasomes, protein machines in the cell that serve as “danger sensors” for infection and which set in motion rapid immune defences against pathogens...
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Flu vaccines fail to protect obese mice
8 August 2016 | By St. Jude Children’s Research Hospital
Using vaccines prepared from killed viruses, the scientists targeted an influenza A H1N1 seasonal flu strain, finding that obese mice are not protected against influenza infections through vaccines, raising concerns about vaccine response in obese humans, who are known to be at an increased risk for severe flu...
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Epigenome mining leads to medulloblastoma discovery
29 January 2016 | By Victoria White
Researchers have identified the cells that likely give rise to the brain tumour subtype Group 4 medulloblastoma, removing a barrier to developing more effective targeted therapies....
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Scientists help launch human dark proteome initiative
10 November 2015 | By Victoria White
The initiative aims to accelerate research into biology's "invisible mass" to provide novel insights into cell function and a new frontier in drug discovery...
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St Jude scientists identify new mechanism of p53-induced cell death
31 July 2015 | By Victoria White
Researchers have identified a new mechanism that the tumour suppressor protein p53 uses to trigger cell death via apoptosis...