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Salk Institute

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Scientists generate human-monkey chimeric embryos

16 April 2021 | By Victoria Rees (Drug Target Review)

An international collaboration has led to the development of monkey embryos able to grow with injected human stem cells.

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Drug candidate for memory loss associated with Alzheimer’s developed

5 August 2020 | By Victoria Rees (Drug Target Review)

A drug called CMS121 given to mice with Alzheimer's-like disease treated their memory loss, allowing them to perform the same as healthy control mice in tests.

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Investigational drug kills pancreatic cells in mice by cutting off cysteine supply

3 April 2020 | By Victoria Rees (Drug Target Review)

Researchers have demonstrated that cysteinase, a new drug compound, can starve pancreatic cells of cysteine supply, causing ferroptosis.

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Imaging technique reveals how HIV drugs bind to viral structure

31 January 2020 | By Victoria Rees (Drug Target Review)

A new study has shown in three dimensions how drugs bind to HIV, which could be used to improve the design of drugs or develop novel therapies.

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Microprotein revealed to regulate cell stress by study

25 October 2019 | By Victoria Rees (Drug Target Review)

Researchers have discovered a microprotein that acts as a regulator of cell stress, which could be used in developing therapies for a wide range of conditions.

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Researchers create blastocyst-like models from mouse cells

21 October 2019 | By Victoria Rees (Drug Target Review)

Mouse blastocyst-like structures called blastoids have been developed by a team which could be used to study early developmental diseases.

news

Two therapeutic targets identified for lung cancer

30 July 2019 | By Drug Target Review

Salk scientists discover a pair of enzymes that drive non-small-cell lung cancer by promoting inflammation which could inform the development of new therapies.

news

Neurons made from skin cells are valid when studying disease

16 January 2019 | By Iqra Farooq (Drug Target Review)

A study has found that using skin cells and transforming them into neurons is a valid approach to study neurodegenerative diseases such as Parkinson's...

news

Scientists develop means to manipulate nuclear pore numbers

19 September 2018 | By Drug Target Review

Researchers in California have developed a method to facilitate control of nuclear pore numbers in cells. The capability is expected to glean valuable information to aid cancer treatment.

article

Flow Cytometry In-Depth Focus 2018

7 September 2018 | By Drug Target Review

Flow cytometry has played a key role in drug development, largely due to its ability to measure up to twenty parameters on single cells or particles suspended in a fluid stream. Conor Fitzpatrick discusses how the rise of high-throughput flow cytometry has contributed to the advancements in drug discovery...

news

Unravelling the mechanism of excess brain growth in autism

8 July 2016 | By Victoria White, Digital Content Producer

Scientists have employed a cutting-edge stem cell technique to unravel the mechanisms driving this phenomenon which affects some individuals with autism...

news

Super-resolution microscopy reveals the surface of T cells

16 June 2016 | By Victoria White, Digital Content Producer

Salk Institute researchers have imaged how vital receptors on the surface of T cells bundle together when activated using super-resolution microscopy...

news

Alteration of protein synthesis could treat neurodegeneration

27 April 2016 | By Victoria White, Digital Content Producer

New Salk research suggests that rapamycin could target the neural damage associated with Leigh syndrome and other forms of neurodegeneration as well...

news

Salk scientists produce functional, insulin-producing cells

12 April 2016 | By Victoria White, Digital Content Producer

The result of their research is the production of hundreds of millions of lab-produced human beta cells that are able to relieve diabetes in mice...

news

‘Outlier’ enzymes identified as potential targets to treat diabetes

30 March 2016 | By Victoria White

Scientists have discovered two enzymes - AIG1 and ADTRP - that appear to play a role in metabolism and inflammation...

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