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Scientists generate human-monkey chimeric embryos
An international collaboration has led to the development of monkey embryos able to grow with injected human stem cells.
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Salk Institute
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Drug candidate for memory loss associated with Alzheimer’s developed
A drug called CMS121 given to mice with Alzheimer's-like disease treated their memory loss, allowing them to perform the same as healthy control mice in tests.
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Investigational drug kills pancreatic cells in mice by cutting off cysteine supply
Researchers have demonstrated that cysteinase, a new drug compound, can starve pancreatic cells of cysteine supply, causing ferroptosis.
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Imaging technique reveals how HIV drugs bind to viral structure
A new study has shown in three dimensions how drugs bind to HIV, which could be used to improve the design of drugs or develop novel therapies.
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Microprotein revealed to regulate cell stress by study
Researchers have discovered a microprotein that acts as a regulator of cell stress, which could be used in developing therapies for a wide range of conditions.
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Researchers create blastocyst-like models from mouse cells
Mouse blastocyst-like structures called blastoids have been developed by a team which could be used to study early developmental diseases.
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Two therapeutic targets identified for lung cancer
Salk scientists discover a pair of enzymes that drive non-small-cell lung cancer by promoting inflammation which could inform the development of new therapies.
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Neurons made from skin cells are valid when studying disease
A study has found that using skin cells and transforming them into neurons is a valid approach to study neurodegenerative diseases such as Parkinson's...
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Scientists develop means to manipulate nuclear pore numbers
Researchers in California have developed a method to facilitate control of nuclear pore numbers in cells. The capability is expected to glean valuable information to aid cancer treatment.
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Flow Cytometry In-Depth Focus 2018
Flow cytometry has played a key role in drug development, largely due to its ability to measure up to twenty parameters on single cells or particles suspended in a fluid stream. Conor Fitzpatrick discusses how the rise of high-throughput flow cytometry has contributed to the advancements in drug discovery...
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Unravelling the mechanism of excess brain growth in autism
8 July 2016 | By Victoria White, Digital Content Producer
Scientists have employed a cutting-edge stem cell technique to unravel the mechanisms driving this phenomenon which affects some individuals with autism...
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Super-resolution microscopy reveals the surface of T cells
16 June 2016 | By Victoria White, Digital Content Producer
Salk Institute researchers have imaged how vital receptors on the surface of T cells bundle together when activated using super-resolution microscopy...
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Alteration of protein synthesis could treat neurodegeneration
27 April 2016 | By Victoria White, Digital Content Producer
New Salk research suggests that rapamycin could target the neural damage associated with Leigh syndrome and other forms of neurodegeneration as well...
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Salk scientists produce functional, insulin-producing cells
12 April 2016 | By Victoria White, Digital Content Producer
The result of their research is the production of hundreds of millions of lab-produced human beta cells that are able to relieve diabetes in mice...
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‘Outlier’ enzymes identified as potential targets to treat diabetes
30 March 2016 | By Victoria White
Scientists have discovered two enzymes - AIG1 and ADTRP - that appear to play a role in metabolism and inflammation...
