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Small molecule RGX-202 prevents metastasis in colorectal cancer
RGX-202 was found to foil a key pathway that cancer cells rely on for energy in mice, presenting a possible new colorectal cancer therapy.
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Rockefeller University
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Two-week-old human embryos reveal origin of Huntington’s disease
Scientists have discovered a signalling pathway alteration in embryos with Huntington’s disease, paving the way for ground-breaking treatments.
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The other end of the antibody: Fc biology and immunotherapy
Dr Björn Frendeus outlines how the growing biology surrounding the inhibitory Fc receptor FcγRIIb defines a target for improving existing and future antibody treatments.
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LY6E identified as potential immunoprotein against SARS-CoV-2
A study has demonstrated that the LY6E protein inhibits SARS-CoV-2 infection in human cell cultures, so a drug mimicking it could be a therapy for COVID-19.
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Researchers discover how gut infections may produce chronic symptoms
A new study into why neurons in the gut die and how the immune system protects them could lead to better treatments for IBS that work by boosting polyamine production.
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New technology developed to screen for Huntington’s treatments
Researchers have created a new technology which enabled them to discover more about the causes of Huntington’s disease and which can be used to test drugs.
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Study reveals new opportunity for gastrointestinal drug design
A study has shown that the organisation of the gut is broken into functional compartments, improving opportunities for gastrointestinal disorder drugs and oral vaccines.
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Uncovering the early origins of Huntington’s disease using CRISPR engineered embryonic stem cells
Researchers have developed a system to model Huntington's in human embryonic stem cells...
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Alzheimer’s Tau protein forms toxic complexes with cell membranes
Researchers identify the sequence and structural factors that drive Tau interaction with membranes...
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Potential new treatment for Fragile X targets one gene to affect many
Inhibitors of chromatin remodelling proteins may be a potential treatment for Fragile X Syndrome...
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Elimination of specific neurons outside the brain by new technique triggers obesity
A research team from Instituto Gulbenkian de Ciencia (IGC, Portugal), developed a new genetic technique that allows the elimination of specific neurons of the peripheral nervous system without affecting the brain.
