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Compound that targets BRAT1 protein could be used to kill cancer cells
Having synthesised the curcusone D compound, researchers demonstrated its promise as the first BRAT1 inhibitor, making it a potential cancer therapy.
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Purdue University
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New 3D cell culture method could enable personalised cancer therapies
A team has extracted single tumour cells from existing cell lines to create 3D cell cultures that could allow for personalised cancer therapies.
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Novel compounds show efficacy against C. diff
Researchers have developed two novel trifluoromethylthio compounds which showed potent activity in protecting mice from Clostridioides difficile (C. diff) infection.
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Translating novel drug success in animals to humans
A team has developed a predictive tool called TransComp-R which could be used to reveal whether new drugs that have been effective in animals will have positive outcomes in humans.
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IL-27 could work as potential immunotherapy against cancers
Researchers have created a new kind of immunotherapy using the interleukin-27 (IL-27) cytokine to effectively combat tumours in vitro and in vivo.
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Drug discovery could be improved with new collapsible basket technology
A collapsible basket technology has been developed to significantly accelerate the analysis process when scientists are developing new medicines.
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Deep learning network used to model protein complexes
A new study has developed a deep learning approach that analyses protein interactions, which could improve the design of drugs in the future.
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Platform may find new options for mental health treatment
A drug discovery platform for mental health treatment could also help to identify mechanisms for the treatment of substance use disorders.
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Five newest developments for imaging in drug research
Imaging methods are used by scientists to identify therapeutic targets and improve drug efficacy. This article lists five of the latest developments for imaging techniques.
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Drug compound could be next-generation treatment for aggressive form of AML
Researchers have developed a series of compounds that work not only on AML with common FLT3 mutation but also drug-resistant AML...
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New imaging tools that trace key breast cancer enzymes may help guide therapies
Series of molecules may provide more reliable relief with fewer side effects...
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MRI tool to cure digestive disorders
Purdue researchers have paved the way for more precise treatment for disorders in the gastrointestinal tract such as gastroparesis...
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Breast tissue simulations address enhanced MRI delays
Researchers address the delay of enhanced MRI cancer detection using simulations of women's breast tissue and higher MRI strengths...
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New 3D ‘nanoscope’ facilitates improved brain imaging for Alzheimer’s research
Scientists in the U.S. have developed a powerful imaging tool to more accurately reproduce visuals of the brain and investigate mechanisms that precede Alzheimer’s symptoms.
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MiR-223 could help treat cancer and asthma
A microRNA that regulates inflammation shows promise as a treatment for inflammatory diseases such as asthma and cancer...
