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Perelman School of Medicine at the University of Pennsylvania

Wasp on a wooden platform [Credit: University of Pennsylvania].

news

Novel antimicrobial molecules derived from wasp venom

13 October 2020 | By Hannah Balfour (Drug Target Review)

Altering the mastoparan-L (mast-L) peptide found in Vespula lewisii wasp venom, researchers created several novel antimicrobial molecules.

HIV viral particles in grey on a black background

news

Novel CAR T-cell therapy could help cure HIV

1 September 2020 | By Hannah Balfour (Drug Target Review)

The designers of the Dual Chimeric Antigen Receptor (CAR) T cell therapy report it slows HIV replication and leads to a smaller viral reservoir in HIV-infected mice.

news

Precise features of CAR T cell-resistant cancer have been identified

3 February 2020 | By Drug Target Review

The mechanism that prevents destruction of cancer cells by CAR T-cell therapy has been identified by researchers in Pennsylvania.

news

New vaccine prevents genital herpes in mice and guinea pigs

23 September 2019 | By Rachael Harper (Drug Target Review)

Almost all animal subjects exposed to genital herpes were protected by the novel vaccine.

news

Blocking kinase could provide treatment for prostate cancer

29 August 2019 | By Victoria Rees (Drug Target Review)

Researchers have found that inhibiting a kinase in mice leads to the death of prostate cancer cells, providing a potential therapeutic target.

news

Blocking mechanism in skin cancer provides potential drug target

20 August 2019 | By Victoria Rees (Drug Target Review)

A study has revealed a drug target for skin cancers which regulates the differentiation of cells and the roles they conduct in the body.

news

Targets for chronic kidney disease treatment

2 October 2018 | By Iqra Farooq (Drug Target Review)

The DAB2 pathway could be a crucial target in treating CKD, as mouse models show a decrease in DAB2 leads to prevention of the condition...

news

Drugs in development for cancer may also fight brain diseases

9 August 2018 | By Drug Target Review

PARP inhibitors show promise in preventing toxic accumulations of brain disease proteins in Penn research study...

news

HRI depletion may be effective in treating sickle cell disease

20 July 2018 | By Drug Target Review

A protein identified in the signalling pathway for haemoglobin production has been identified as a possible target to treat sickle cell disease (SCD)...

New target for treating heart failure identified by Penn Medicine researchers

news

New target for treating heart failure identified by Penn Medicine researchers

13 June 2018 | By Drug Target Review

Reversing modifications in diseased heart muscle cell struts called microtubules (MT) can lessen the stiffness and improve the beating strength of these cells isolated from transplant patients with heart failure.

news

Genomic medicine may one day revolutionise cardiovascular care

30 May 2018 | By Drug Target Review

A new scientific statement summarises the state-of-the-science of genomic medicine...

news

IL-25 molecule linked to nasal polyps

30 May 2018 | By Drug Target Review

Study could lead to the development of new treatments for common sinus conditions...

Penn study finds that different diseases elicit distinct sets of exhausted T cells

news

Penn study finds that different diseases elicit distinct sets of exhausted T cells

17 May 2018 | By Drug Target Review

Using data from multiple molecular databases, researchers from the University of Pennsylvania have found nine distinct types of exhausted T cells (‘Tex’), which could have implications for fighting chronic infections, autoimmunity, and cancer.

Diverse Parkinson’s-related disorders may stem from different strains of same protein

news

Diverse Parkinson’s-related disorders may stem from different strains of same protein

10 May 2018 | By Drug Target Review

Researchers found that the type of brain cell afflicted in Parkinson’s-related brain disorders dictates which pathological form of α-synuclein (α-syn) protein becomes the disease culprit.

news

Study uncovers therapeutic targets for aggressive triple-negative breast cancers

5 February 2018 | By Dr Zara Kassam (Drug Target Review)

New findings have made inroads into a strategy to identify TNBC tumours at risk for metastasis...

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Perelman School of Medicine at the University of Pennsylvania