![Wasp on a wooden platform [Credit: University of Pennsylvania].](https://drug.russellpublishing.co.uk/wp-content/uploads/Vespula-lewisii-wasp-750x500.jpg)
![Wasp on a wooden platform [Credit: University of Pennsylvania].](https://drug.russellpublishing.co.uk/wp-content/uploads/Vespula-lewisii-wasp-e1602594547599.jpg)
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Novel antimicrobial molecules derived from wasp venom
Altering the mastoparan-L (mast-L) peptide found in Vespula lewisii wasp venom, researchers created several novel antimicrobial molecules.
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Perelman School of Medicine at the University of Pennsylvania
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Novel CAR T-cell therapy could help cure HIV
The designers of the Dual Chimeric Antigen Receptor (CAR) T cell therapy report it slows HIV replication and leads to a smaller viral reservoir in HIV-infected mice.
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Precise features of CAR T cell-resistant cancer have been identified
The mechanism that prevents destruction of cancer cells by CAR T-cell therapy has been identified by researchers in Pennsylvania.
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New vaccine prevents genital herpes in mice and guinea pigs
Almost all animal subjects exposed to genital herpes were protected by the novel vaccine.
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Blocking kinase could provide treatment for prostate cancer
Researchers have found that inhibiting a kinase in mice leads to the death of prostate cancer cells, providing a potential therapeutic target.
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Blocking mechanism in skin cancer provides potential drug target
A study has revealed a drug target for skin cancers which regulates the differentiation of cells and the roles they conduct in the body.
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Targets for chronic kidney disease treatment
The DAB2 pathway could be a crucial target in treating CKD, as mouse models show a decrease in DAB2 leads to prevention of the condition...
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Drugs in development for cancer may also fight brain diseases
PARP inhibitors show promise in preventing toxic accumulations of brain disease proteins in Penn research study...
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HRI depletion may be effective in treating sickle cell disease
A protein identified in the signalling pathway for haemoglobin production has been identified as a possible target to treat sickle cell disease (SCD)...
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New target for treating heart failure identified by Penn Medicine researchers
Reversing modifications in diseased heart muscle cell struts called microtubules (MT) can lessen the stiffness and improve the beating strength of these cells isolated from transplant patients with heart failure.
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Genomic medicine may one day revolutionise cardiovascular care
A new scientific statement summarises the state-of-the-science of genomic medicine...
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IL-25 molecule linked to nasal polyps
Study could lead to the development of new treatments for common sinus conditions...
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Penn study finds that different diseases elicit distinct sets of exhausted T cells
Using data from multiple molecular databases, researchers from the University of Pennsylvania have found nine distinct types of exhausted T cells (‘Tex’), which could have implications for fighting chronic infections, autoimmunity, and cancer.
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Diverse Parkinson’s-related disorders may stem from different strains of same protein
Researchers found that the type of brain cell afflicted in Parkinson’s-related brain disorders dictates which pathological form of α-synuclein (α-syn) protein becomes the disease culprit.
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Study uncovers therapeutic targets for aggressive triple-negative breast cancers
New findings have made inroads into a strategy to identify TNBC tumours at risk for metastasis...
