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North Carolina State University

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Frameshifting method could be a new mast cell cancer treatment

12 August 2021 | By Anna Begley (Drug Target Review)

Frameshifting therapy has been shown to reduce the number of mast cells by “mutating” mRNA, showing promise as a new cancer treatment.

news

New spray shown to help heal heart attack damage in rats

15 July 2021 | By Anna Begley (Drug Target Review)

A team have developed a minimally invasive exosome spray that helped repair rat hearts after myocardial infarction.

news

Nanodecoy therapy neutralises SARS-CoV-2 in macaques

18 June 2021 | By Victoria Rees (Drug Target Review)

Lung spheroid cells can act as nanodecoys for the SARS-CoV-2 Spike protein to bind to, according to a new pre-clinical study.

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Researchers develop new biosynthesis process to create antibiotics

14 April 2021 | By Victoria Rees (Drug Target Review)

Scientists have discovered that manipulating residues enables precision during the antibiotic biosynthesis assembly line.

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Three common antiviral drugs effective against SARS-CoV-2 in vitro

25 March 2021 | By Victoria Rees (Drug Target Review)

A team has shown that tilorone, quinacrine and pyronaridine are effective at inhibiting the replication of SARS-CoV-2 in vitro.

news

Study reveals microRNA as promising hair regrowth drug target

28 July 2020 | By Victoria Rees (Drug Target Review)

Researchers have revealed that the microRNA miR-218-5p promoted hair growth in mice, so is a promising drug target for hair loss.

news

CRISPR-Cas3 used to combat C. difficile in lab and mice

11 March 2020 | By Victoria Rees (Drug Target Review)

Researchers have shown that CRISPR-Cas3 can successfully attack C. difficile in vitro and in mice, by causing DNA damage to the pathogen.

white laboratory rat sat on scientists gloved hand

news

Inhaling stem cell secretome could be a more effective pulmonary fibrosis treatment

2 March 2020 | By Hannah Balfour (Drug Target Review)

Rodent models of pulmonary fibrosis have been used to show that lung spheroid cell secretome therapy is as effective as stem cell secretome treatment.

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Researchers develop biosensor with real-time oxygen monitoring

21 August 2018 | By Iqra Farooq (Drug Target Review)

In a study, researchers have developed a biosensor concept using organs-on-a-chip to measure the levels of oxygen in real-time...

news

Prenatal exposure to BPA at low levels can affect gene expression

1 November 2017 | By Dr Zara Kassam (Drug Target Review)

Prenatal exposure to BPA affects gene expression related to sexual differentiation and neurodevelopment in the developing brain...

news

New technique speeds up chemical screening

23 August 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have developed a high-throughput technique that can determine if a chemical has the potential to activate key genes in seconds...

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