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Karolinska Institutet

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CRISPR-Cas9 variant shows high precision in gene editing

2 October 2019 | By Nikki Withers (Drug Target Review)

The newly identified variant could play a role in gene therapies that require high accuracy and precision.

news

Nervous system discovery overturns previous theory

12 September 2019 | By Rachael Harper (Drug Target Review)

A ground-breaking nervous system discovery could be significant for the treatment of different neurological diseases.

news

Researchers develop new DNA microscopy technique

6 September 2019 | By Victoria Rees (Drug Target Review)

The novel method for imaging molecules in cells and tissue samples, called DNA microscopy, could improve knowledge of disease development.

news

Study reveals antioxidant role in spread of lung cancer

1 July 2019 | By Victoria Rees (Drug Target Review)

Researchers have discovered that lung cancer cells metastasise using antioxidants, informing potential future therapies.

news

Inhibiting inflammation by blocking release of TNF alpha

16 November 2018 | By Drug Target Review

Researchers at Karolinska Institutet collaborated with other researchers to develop a compound that prevents inflammation by blocking release of TNF alpha...

news

Protein adhesion complex cell structure identified

23 October 2018 | By Drug Target Review

A cell structure identified has given an insight into how cells attach to their surroundings, and could be used to discover potential actions of new drugs...

news

Antiphospholipid antibodies linked to heart attacks

23 October 2018 | By Drug Target Review

Levels of antiphospholipid antibodies, which are associated with rheumatic diseases, are also elevated in myocardial infarction without any autoimmune co-morbidity...

news

Structural map of bacterial toxins identified

18 September 2018 | By Iqra Farooq (Drug Target Review)

A three-dimensional structural map of bacterial toxins has been identified for the bacterium Pseudomonas aeruginosa...

news

Neurons in the inner ear can lead to new therapies for hearing disorders

12 September 2018 | By Drug Target Review

Researchers have identified four types of neurons in the peripheral auditory system, three of which are new to science...

news

CRISPRa used to reprogramme skin cells into pluripotent stem cells

6 July 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have now for the first time succeeded in converting skin cells into pluripotent stem cells by activating the cell's own genes...

news

CRISPR-Cas9 tool could increase cancer risk

12 June 2018 | By Dr Zara Kassam (Drug Target Review)

Therapeutic use of gene editing with the so-called CRISPR-Cas9 technique may inadvertently increase the risk of cancer...

news

Cell types underlying schizophrenia identified

23 May 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have identified the cell types underlying schizophrenia, the findings offer a roadmap for the development of new therapies to target the condition...

New treatment for aggressive breast cancer

news

New treatment for aggressive breast cancer

14 March 2018 | By Drug Target Review

Researchers have uncovered a way to treat aggressive tumours through manipulation of the connective tissue cells of the tumour.

news

Single-cell RNA sequencing provides molecular atlas to study brain diseases

15 February 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have detailed a molecular atlas of the cells that form the brain's blood vessels and the life-essential blood-brain barrier providing clues to which cell types are involved in different diseases...

news

Improved accuracy when testing cancer drugs

3 July 2017 | By Niamh Marriott (Drug Target Review)

A method to more accurately test anti-cancer drugs has now been developed at the Sahlgrenska Academy, University of Gothenburg.

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