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Metal-based molecule could inhibit build-up of Alzheimer’s peptides

15 July 2021 | By Anna Begley (Drug Target Review)

UK researchers have created a metal-based molecule that inhibits the build-up of Alzheimer’s-associated peptide, amyloid-β, in lab tests.

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AI platform developed to reveal how bacteria infect intestines

27 April 2021 | By Victoria Rees (Drug Target Review)

A new artificial intelligence (AI) method has been created to uncover which proteins enable bacteria to infect human intestines.

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Molecule in body that blocks antibody binding to SARS-CoV-2 discovered

23 April 2021 | By Victoria Rees (Drug Target Review)

Biliverdin attaches to a region of the SARS-CoV-2 Spike protein, stabilising it so that it is not able to expose its structure to antibodies, a new study has shown.

article

Broad T-cell responses: designing a rhinovirus vaccine

31 March 2021 | By Nikki Withers (Drug Target Review)

The multiple serotypes of rhinovirus have presented difficulties for vaccine developers. Now, a team led by Professor Gary McLean from London Metropolitan University and Imperial College London, alongside Professor Sebastian Johnston from Imperial, has formulated a potential vaccine. Nikki Withers spoke to McLean to discover how the vaccine works and…

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UK Government to fund four studies investigating long COVID

19 February 2021 | By Victoria Rees (Drug Target Review)

The UK Government will give £18.5 million in funding to four studies researching the causes and potential treatments of long COVID.

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New probes shine a light on the role of four-stranded DNA in human cells

14 January 2021 | By Hannah Balfour (Drug Target Review)

A better understanding of the role of four-stranded DNA (G-quadruplex) could enhance cancer therapeutics, said the developers of the probes.

Three-dimensional (3D) illustration of amyloid beta plaques (brown mesh-like shapes) forming between neurons and disrupting their function. Amyloid plaques are a hallmark of Alzheimer’s Disease.

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Developing drugs for disordered proteins

6 November 2020 | By Hannah Balfour (Drug Target Review)

Scientists have developed a drug-like molecule to target amyloid-beta, a disordered protein implicated in Alzheimer's disease that has been considered undruggable.

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UK government funds 21 new research projects into COVID-19

20 April 2020 | By Victoria Rees (Drug Target Review)

A total of 21 COVID-19 research projects have been granted funding by the UK government, including vaccine and therapeutic development.

news

Syndecan-4 cell sensory protrusions activate hallmarks of cancer

7 January 2020 | By Hannah Balfour (Drug Target Review)

A study has revealed that activation of syndecan-4 sensory protrusions extending from cells may be a future target for cancer therapy.

news

New way to target treatment-resistant cancers identified

22 October 2019 | By Rachael Harper (Drug Target Review)

A new mechanism by which cancer cells become resistant to chemotherapy has been found which could lead to a new target for drugs.

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Weapon bacteria could be copied to create new forms of antibiotics

1 October 2019 | By Rachael Harper (Drug Target Review)

New antibiotics could be designed by discovering the mechanism a weapon bacteria uses to vanquish their competitors.

news

Possible target found for idiopathic pulmonary fibrosis treatment

25 September 2019 | By Rachael Harper (Drug Target Review)

A new study shows that using therapeutic antibodies to block the interleukin-11 protein can reverse idiopathic pulmonary fibrosis.

news

How bacteria behind hospital infections block out antibiotics revealed

3 September 2019 | By Rachael Harper (Drug Target Review)

Scientists have shown that drug-resistant bacteria infections shut out antibiotics by closing tiny doors in their cell walls.

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Breast cancer ‘sleeper cells’ could be formed after drug treatment

2 September 2019 | By Rachael Harper (Drug Target Review)

Breast cancer medicines may force some cancer cells into 'sleeper mode', allowing them to potentially come back to life after treatment.

news

Nanoscale ‘tweezers’ for individual cell biopsies

4 December 2018 | By Iqra Farooq (Drug Target Review)

Researchers have developed nanoscale 'tweezers' used to investigate single living cells, which could help to identify why healthy cells become diseased...

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