Mass spectrometry approach allows researchers to make precise protein measurements 3 March 2020 | By Victoria Rees (Drug Target Review) A new method for weighing proteins at the atom level, called individual ion mass spectrometry, has been developed by American researchers.
Researchers find drug improves cancer immunotherapy in mice 3 March 2020 | By Victoria Rees (Drug Target Review) A study has shown that in mice, the GKT137831 drug makes tumours more sensitive to immunotherapy, so could be used to improve cancer treatments.
Stainless imaging developed by adding infrared to standard microscopes 2 March 2020 | By Victoria Rees (Drug Target Review) A new method to image cancerous tissues has been created by researchers who have paired infrared measurements with high-resolution optical images.
Novel antibody breaks bacterial biofilms and prevents sepsis in mice 2 March 2020 | By Victoria Rees (Drug Target Review) A new monoclonal antibody has been discovered which disassociates bacterial biofilms and stops bacteria from entering into circulation has been tested in mice.
New gene therapy for Huntington’s demonstrates success in mice 2 March 2020 | By Victoria Rees (Drug Target Review) Researchers have developed a new regenerative gene therapy using neurogenic differentiation, which has shown efficacy treating Huntington's disease in mice.
Inhaling stem cell secretome could be a more effective pulmonary fibrosis treatment 2 March 2020 | By Hannah Balfour (Drug Target Review) Rodent models of pulmonary fibrosis have been used to show that lung spheroid cell secretome therapy is as effective as stem cell secretome treatment.
Metal-containing compounds could lead to new antibacterials 2 March 2020 | By Hannah Balfour (Drug Target Review) International collaboration has shown that compounds with metals in them show antibacterial activity against MRSA, E. coli and A. baumannii.
Study reveals how immune system handles fungal and viral infections 28 February 2020 | By Victoria Rees (Drug Target Review) Researchers have studied how the human body responds to viral infection when already infected by fungi, offering insights into the immune system.
3D models developed by researchers to optimise protein design 28 February 2020 | By Victoria Rees (Drug Target Review) A computational programme has been created by researchers to aid in the design of proteins for therapeutics, to predict interactions.
Naphthyridine-Azaquinolone reverses Huntington’s DNA repeats in mouse model 28 February 2020 | By Hannah Balfour (Drug Target Review) Researchers show Naphthyridine-Azaquinolone (NA) could be a possible future therapy able to slow the progression and improve the symptoms of Huntington’s disease.
New T-cell discovery could lead to treatments for both bacterial infections and autoimmune conditions 28 February 2020 | By Hannah Balfour (Drug Target Review) A novel highly activated form of T cells could be suppressed to treat autoimmune conditions and activated in treating bacterial infections.
Boosting natural killer cells in mice with eczema relieves condition 28 February 2020 | By Victoria Rees (Drug Target Review) Researchers have found that using IL-15 to boost natural killer cell numbers in mice helps to combat eczema and could be a therapeutic strategy for patients.
Infrared light used to improve photodynamic therapy in model tumours 27 February 2020 | By Victoria Rees (Drug Target Review) Researchers have developed a compound that can be activated with infrared light to kill cancer cells in model tumours, advancing the possibilities of photodynamic therapy.
Antibacterial cannabinoid compound identified by researchers 27 February 2020 | By Victoria Rees (Drug Target Review) A study has revealed that the compound cannabigerol (CBG) is effective as an antibacterial in mice, by preventing bacteria from forming biofilms.
Possible novel cognitive anti-ageing targets identified 27 February 2020 | By Hannah Balfour (Drug Target Review) Researchers have shown that two epigenetic regulators could be targeted to improve cognitive and behavioural decline in age-related diseases like Alzheimer’s.
