Increasing ion channel function in cancer T cells could be new immunotherapy 11 March 2020 | By Victoria Rees (Drug Target Review) Researchers have found that there is less calmodulin binding to ion channels in the T cells from cancer patients, presenting a new immunotherapeutic target.
Antibodies stimulate microglia to degrade Alzheimer’s amyloid plaques 11 March 2020 | By Hannah Balfour (Drug Target Review) A novel antibody has been shown to stimulate microglia to degrade amyloid plaques in a murine model of Alzheimer’s disease.
Proteins vital for hepatitis B infection discovered by researchers 10 March 2020 | By Victoria Rees (Drug Target Review) A new study has revealed five factors and proteins that hepatitis B infection needs for replication of its DNA, providing insight into the disease.
Förster resonance energy transfer development enables imaging of single molecules 10 March 2020 | By Victoria Rees (Drug Target Review) Using fluorescent markers, researchers have developed Förster resonance energy transfer (FRET) to image the assembly, functions and interactions of molecules.
Structure of commonly mutated histone chaperone revealed by new study 10 March 2020 | By Hannah Balfour (Drug Target Review) Researchers have shown how ATAD2, a histone chaperone protein, may load histones on to DNA in order to create the chromatin structure.
TAZ gene therapy reverses Barth syndrome in mice 10 March 2020 | By Victoria Rees (Drug Target Review) Researchers have successfully treated cardiac dysfuntion in mice models of Barth syndrome by using a gene therapy to replace TAZ.
Novel cell reprogramming cocktail could advance regenerative medicine 10 March 2020 | By Hannah Balfour (Drug Target Review) Scientists have showed that a three inhibitors (3i) cocktail could reprogramme fibroblasts to a naïve embryonic stem cell-like state and remove disease-associated epigenetic changes.
Master controller regions could be targeted for novel Parkinson’s therapies 9 March 2020 | By Hannah Balfour (Drug Target Review) Scientists have identified two master controller regions that are essential for alpha-synuclein aggregation and could be targeted by future therapies.
Drug discovery could be improved with new collapsible basket technology 9 March 2020 | By Rachael Harper (Drug Target Review) A collapsible basket technology has been developed to significantly accelerate the analysis process when scientists are developing new medicines.
Drug discovered for Postural Orthostatic Tachycardia Syndrome (POTS) 9 March 2020 | By Rachael Harper (Drug Target Review) A novel therapy, tested ex vivo, has been successful at correcting the dysfunctional body mechanism in Postural Orthostatic Tachycardia Syndrome (POTS).
TEX264 protein could be targeted to help protect DNA from damage 9 March 2020 | By Hannah Balfour (Drug Target Review) Scientists have identified that the TEX264 protein and associated enzymes protect the genome from damage, which could lead to new anti-ageing and neurodegeneration therapies.
Researchers develop imaging technique to study 3D-printed brain tumours 9 March 2020 | By Victoria Rees (Drug Target Review) A new method has been created by researchers to 3D bioprint tumours and image glioblastomas for the study of therapeutics.
Researchers identify enzyme critical for regulating cell signalling 6 March 2020 | By Victoria Rees (Drug Target Review) An enzyme that adds a cell-signalling code to proteins has been identified by researchers, who say their discovery could aid in the development of cancer therapies.
Stem cells that can grow new bone discovered by researchers 6 March 2020 | By Victoria Rees (Drug Target Review) A new population of stem cells that can generate bone has been revealed by researchers, which they say could have implications in regenerative medicine.
Enhancing the speed of atomic force microscopy for biological samples 6 March 2020 | By Hannah Balfour (Drug Target Review) Researchers have applied for a patent for their innovative cantilever and vibrating plate technique which they say could increase the speed of atomic force microscopy on fragile samples.
