New label-free microscopy method enables imaging inside living cells
By combining quantitative phase microscopy and molecular vibrational imaging, researchers have created a new label-free microscopy technique.
List view / Grid view
News
Binding site of drug compound and tumour suppressor protein revealed
Using cyro-electron microscopy, researchers have imaged the binding site between a molecule and the tumour suppressor protein PP2A, enabling optimisation of the drug compound.
Nanobodies developed to image COVID-19 Spike protein
Researchers in the UK have selected nanobodies that bind with high affinity to the Spike protein on the COVID-19 coronavirus, enabling stabilisation for imaging.
Chemical tool developed to examine lipids in living cells
A new method has been developed by researchers using chemical tools activated by light to influence lipid concentration in living cells.
UK government funds 21 new research projects into COVID-19
A total of 21 COVID-19 research projects have been granted funding by the UK government, including vaccine and therapeutic development.
Novel gene promoters could improve gene therapies for neurological diseases
Novel promoters based on those in the herpes viruses, enabled delivery of larger genes and increased the period they were active in the nervous system.
Novel visualisation platform to aid understanding of COVID-19 strain evolution
The visualisation platform is being used to analyse how the SARS-CoV-2 virus causing COVID-19 is evolving and could be used to inform drug design.
Cynomolgus macaques: a promising animal model of COVID-19 infection?
Researchers comparing the effects of SARS-CoV-2, SARS-CoV and MERS-CoV in cynomolgus macaques suggest they could be an effective animal model for testing COVID-19 therapeutics.
Universal Ebola vaccine shows promise in pre-clinical trials
An Ebola vaccine that has been tested in animals could potentially be used to neutralise four species of the virus, say the researchers.
Screening 10,000 compounds identifies six potential COVID-19 therapeutics
High-throughput screening of thousands of compounds has revealed several candidates, including lead compound ebselen, with the potential for treating COVID-19.
Drug compound used to overcome chemotherapy resistance in mice
Researchers testing 2-deoxy-D-glucose in mouse models of ovarian cancer report that the compound significantly improves the effectiveness of the chemotherapy drug, carboplatin.
Specialised proteins could halt cytokine storms in COVID-19 patients
Researchers who developed modified proteins say this could be used in the fight against COVID-19, by tackling cytokine storms.
VP3 protein: revealing the structure of a potential rotavirus drug target
Researchers hope that by revealing the rotavirus VP3 protein structure and mRNA capping functions, novel antivirals could be designed to prevent or combat rotavirus infections.
Severe COVID-19 symptoms may be caused by overactive neutrophils
An international consortium suggest that the severe symptoms of COVID-19, including Acute Respiratory Distress Syndrome (ARDS), could be caused by Neutrophil Extracellular Traps (NETs).
Consortia of microbes could reduce inflammation and promote colon health, say researchers
A study has shown that two products of bacterial bile metabolism boost the conversion of precursor T cells into peripheral Tregs, which suppress chronic inflammation in the colon.
