Novel target for Sjögren’s Syndrome identified by researchers 6 May 2020 | By Victoria Rees (Drug Target Review) A molecule called microRNA-744, which influences inflammation, has been revealed by researchers as a new drug target for Sjögren's Syndrome.
Study finds activation sequence of COVID-19 S protein is cleaved by furin protease 6 May 2020 | By Victoria Rees (Drug Target Review) Researchers have shown that the activation sequence the SARS-CoV-2 S protein is cleaved by the cellular enzyme furin which is also required for the infection of lung cells.
Immuno-oncology assay market predicted to be worth $6bn by 2026 6 May 2020 | By Victoria Rees (Drug Target Review) A rise in biotechnology R&D activities is expected to drive the growth of the immuno-oncology assay market, with a CAGR of 10.6 percent.
Researchers identify monoclonal antibody to neutralise COVID-19 5 May 2020 | By Victoria Rees (Drug Target Review) An antibody that neutralises both SARS-CoV and SARS-CoV-2 in cell cultures has been discovered by researchers and could be used to treat COVID-19.
Mass spec used to reveal glycan structures of COVID-19 Spike protein 5 May 2020 | By Victoria Rees (Drug Target Review) High-resolution mass spectrometry has been used by researchers to map the glycan-processing states of the Spike protein of the SARS-CoV-2 virus, which causes COVID-19.
Unique mutation in SARS-CoV-2 virus identified from next-generation sequencing 5 May 2020 | By Victoria Rees (Drug Target Review) Next-generation sequencing has revealed an 81-base pair mutation of the SARS-CoV-2 virus, which could be used to develop new antivirals or vaccines.
Cytokine storms and T-cell counts may offer clues on COVID-19 treatment 4 May 2020 | By Victoria Rees (Drug Target Review) According to a new study, treatments for COVID-19 should focus on cytokines and T-cell counts and their function, rather than patient respiratory function.
Novel antibiotic peptide fights ‘superbug’ lung infections in mice 4 May 2020 | By Victoria Rees (Drug Target Review) Scientists have developed a new antimicrobial peptide therapy named D8 with high efficacy and low toxicity in mice which could be used to fight lung infections.
Researchers reveal cryo-EM structure of remdesivir bound to SARS-CoV-2 4 May 2020 | By Victoria Rees (Drug Target Review) A group of researchers has used cryo-EM to discover the structure of the remdesivir-bound RNA complex of SARS-CoV-2 and explain how the drug inhibits COVID-19 viral replication.
Tregs produced by mesenchymal stromal cells with novel technique 1 May 2020 | By Victoria Rees (Drug Target Review) By culturing blood cells with mesenchymal stromal cells (MSCs), researchers induced the production of cells with the same functionality as Tregs.
Researchers reveal structure of mega-enzymes from bacteria and fungi 1 May 2020 | By Victoria Rees (Drug Target Review) Researchers have uncovered the structure of nonribosomal peptide synthetases (NRPSs), an important ingredient in drug production.
Researchers suggest COVID-19 therapeutics needed to target blood vessel leakage 1 May 2020 | By Victoria Rees (Drug Target Review) According to researchers, ACE2 receptors disappear from lung cells during COVID-19, allowing small blood vessels to leak at the site of infection, presenting a new drug target.
Three new assays to test COVID-19 antivirals developed 30 April 2020 | By Victoria Rees (Drug Target Review) A series of three new assays to screen for drug compounds or proteins that combat the COVID-19 coronavirus has been developed.
Collaboration to identify novel COVID-19 drug targets announced 30 April 2020 | By Hannah Balfour (Drug Target Review) Bringing together protein science, drug discovery experience and innovative technology, a new collaboration aims to identify novel drug targets for COVID-19.
Silicates from soil aid in triggering blood clotting, reveal researchers 30 April 2020 | By Victoria Rees (Drug Target Review) A new study has revealed that the presence of soil in wounds helps to activate a blood protein known as coagulation Factor XII, leading to clotting.
