Study identifies potential therapeutic targets for most lethal pancreatic cancer 15 September 2020 | By Hannah Balfour (Drug Target Review) The detailed analysis of adenosquamous cancer of the pancreas (ASCP) suggested FGFR and RORC were two promising therapeutic targets.
Novel molecule restores lost connections in spinal cords and brains of mice 14 September 2020 | By Victoria Rees (Drug Target Review) Researchers have developed a molecule that can restore lost connections in the spinal cords and brains of mice with cerebellar ataxia, Alzheimer's disease and spinal cord injury.
Researchers target previously “undruggable” enzyme to treat Duchenne muscular dystrophy in cells 14 September 2020 | By Victoria Rees (Drug Target Review) By targeting a previously undiscovered allosteric site on a DMD-associated enzyme, researchers found muscle cell conditions improved.
Stem cells used to identify potential treatments for Parkinson’s disease 14 September 2020 | By Victoria Rees (Drug Target Review) Scientists have found two active substances that allowed cells to reactivate the production of a protein that prevents the onset of Parkinson's disease.
Tool to track SARS-CoV-2 mutations could inform drug development 11 September 2020 | By Victoria Rees (Drug Target Review) A new tool called COVID-3D that monitors SARS-CoV-2 genome mutations could aid drug and vaccine development, its creators say.
Concanamycin A antibiotic that targets Nef protein could cure HIV 11 September 2020 | By Victoria Rees (Drug Target Review) Researchers have revealed that the antibiotic concanamycin A targets a protein called Nef, allowing the immune system to destroy HIV in cells.
Researchers capture images of cells infected with SARS-CoV-2 11 September 2020 | By Victoria Rees (Drug Target Review) Using scanning electron microscopy, researchers have captured images of epithelial cell cultures infected by SARS-CoV-2.
Two drug candidates show promise against COVID-19 in organoid system 10 September 2020 | By Victoria Rees (Drug Target Review) Following their success in organoid systems, two drug candidates are now to be administered to ferrets and tested against COVID-19.
Researchers visualise how orthoreovirus assembles inside infected cells 10 September 2020 | By Victoria Rees (Drug Target Review) Researchers have captured the assembly of orthoreovirus, part of the Reoviridae family, inside infected cells using cryo-electron tomography.
Human genome-produced RNA discovered on surface of cells 10 September 2020 | By Victoria Rees (Drug Target Review) Human genome-produced RNA has been found on the surface of human cells, which researchers say could be easier for therapeutics to reach.
Down syndrome study reveals potential leukaemia drug targets 9 September 2020 | By Hannah Balfour (Drug Target Review) The study evaluating Down syndrome endothelial cells presented novel drug targets for leukaemia and suggested why DS patients may be at greater risk from the cancer.
Treatments for macrophage activation syndrome could reduce COVID-19 mortality 9 September 2020 | By Hannah Balfour (Drug Target Review) Researchers suggest possible therapies for macrophage activation syndrome (MAS), a feature of cytokine storm and a major cause of death in severe COVID-19 patients.
Organoids grown from stem cells could treat children with intestinal failure 8 September 2020 | By Victoria Rees (Drug Target Review) Intestinal organoids have been grown by researchers using stem cells from patient tissues that could lead to personalised transplants for children with intestinal failure.
Study shows how cone cells in the retina form connections with brain 8 September 2020 | By Victoria Rees (Drug Target Review) Researchers have discovered how cone cells in the retina send information to the brain, which could be used in the development of treatments for blindness.
Genetic analysis reveals disease-causing protein drug targets 8 September 2020 | By Victoria Rees (Drug Target Review) An analysis of blood protein levels has supported drug target prioritisation by identifying the causal effects of proteins on diseases, a team has shown.
