New database to track neurological symptoms of COVID-19 28 January 2021 | By Hannah Balfour (Drug Target Review) NeuroCOVID will be a resource of clinical information and biospecimens from people who experience neurological problems associated with SARS-CoV-2 infection.
TALEN is a more efficient gene editing tool for tightly packed DNA, finds study 28 January 2021 | By Hannah Balfour (Drug Target Review) TALEN was shown to be almost five times more efficient than CRISPR-Cas9 at locating and editing genes in heterochromatin.
Melatonin could act as barrier against SARS-CoV-2 infection 28 January 2021 | By Victoria Rees (Drug Target Review) Researchers have suggested using melatonin in a nasal spray to create a protective barrier against SARS-CoV-2 in pre-symptomatic patients.
Scientists discover new promising target for diabetes treatment 28 January 2021 | By Victoria Rees (Drug Target Review) Researchers have found a druggable insulin inhibitory receptor named inceptor that could provide a drug target for diabetes.
New database could inform the development of treatments to slow ageing 27 January 2021 | By Hannah Balfour (Drug Target Review) The database could save substantial resources for those wanting to do pre-clinical studies of interventions for age-related diseases, said scientists.
Biomarker in blood could determine severity of COVID-19 27 January 2021 | By Victoria Rees (Drug Target Review) A study has shown that patients with severe COVID-19 have significantly elevated levels of M-MDSCs in their blood compared with healthy individuals.
Novel compound named BC1618 could serve as new diabetes drug 27 January 2021 | By Victoria Rees (Drug Target Review) Researchers have identified a new compound that improved responses to insulin and treated diabetes in obese mouse models.
Attenuated vaccine could combat fatal Leptospira bacteria 27 January 2021 | By Hannah Balfour (Drug Target Review) A single vaccination with a mutated Leptospira bacteria prevented rodent models from developing leptospirosis, the most fatal type of zoonotic disease worldwide.
Novel antibody candidate could offer pan-coronavirus protection 26 January 2021 | By Hannah Balfour (Drug Target Review) The lead candidate, ADG2, was able to neutralise SARS-CoV and various strains of SARS-CoV-2, including those that are resistant to currently available antibody treatments.
Two novel molecules to potentially combat asthma discovered 26 January 2021 | By Victoria Rees (Drug Target Review) Researchers have discovered that giving L-tyrosine and PCS to mice prevents lung inflammation and an allergic asthma response.
In vitro model could aid the development of fatty liver disease treatments 26 January 2021 | By Hannah Balfour (Drug Target Review) The patient-derived model of non-alcoholic fatty liver disease (NAFLD) accurately reproduced the complex human metabolic pathways involved in the development of the disease.
Researchers develop novel way to identify new cancer drugs 26 January 2021 | By Victoria Rees (Drug Target Review) A team has developed a new way to discover peptide therapeutics that inhibit HDAC enzymes and are effective against cancer.
NSAIDs could be damaging to COVID-19 patients, dependent on timing, suggests study 25 January 2021 | By Hannah Balfour (Drug Target Review) In murine models of COVID-19, researchers found that non-steroidal anti-inflammatory drugs (NSAIDs) can suppress the inflammatory response and production of antibodies.
CAR T cells targeting the CEACAM7 protein show promise in pancreatic cancer 25 January 2021 | By Hannah Balfour (Drug Target Review) CAR T cells modified to recognise CEACAM7 were able to eliminate pancreatic ductal adenocarcinoma cells in a late-stage model without toxic effects on healthy tissue.
Rhesus macaques with SARS-CoV-2 develop promising immune response 25 January 2021 | By Victoria Rees (Drug Target Review) A study has shown that the immune response of rhesus macaques with SARS-CoV-2 could be reproduced with a vaccine.
![A microscopy image of Leptospira bacteria [Credit: Wunder et al. (CC BY 4.0)].](https://drug.russellpublishing.co.uk/wp-content/uploads/Leptospira-bacteria.jpg)
