Researchers identify antibodies with potent effects against malaria 8 March 2021 | By Victoria Rees (Drug Target Review) Six antibodies specific to the circumsporozoite protein of the malaria parasite have shown promise as therapeutic interventions, a study has shown.
Engineered stem cells shown to target breast cancer that metastasises to brain 8 March 2021 | By Victoria Rees (Drug Target Review) A team have shown that a tumour-suppressing and killing molecule delivered to the brain by stem cells has been successful in mice.
SARS-CoV-2 mAb cocktail effective against all known variants of virus 8 March 2021 | By Victoria Rees (Drug Target Review) A monoclonal antibody (mAb) cocktail, that targets sites on the Spike protein other than the E484K residue, can neutralise SARS-CoV-2.
AI-based method used to screen for Alzheimer’s disease drugs 5 March 2021 | By Victoria Rees (Drug Target Review) Researchers have used artificial intelligence to screen 80 FDA-approved drugs and reveal which could be used as Alzheimer's treatments.
SARS-CoV-2 mutations complicate killer T cell immune response, study shows 5 March 2021 | By Victoria Rees (Drug Target Review) Researchers have found that mutations in SARS-CoV-2 T cell epitopes enable the virus to evade the immune response of killer T cells.
Researchers study iPSCs to uncover genetic causes of disease 5 March 2021 | By Victoria Rees (Drug Target Review) Sequencing and transcriptome data on iPSCs has been used to identify correlations between genetic variants and expression patterns.
Researchers identify key enzymes to synthesise natural products 5 March 2021 | By Victoria Rees (Drug Target Review) A team has discovered how enzymes control the formation of bioactive rubromycin-polyketides, which could be used to bioengineer new compounds.
Structure of protein that triggers neurodegeneration isolated and analysed 4 March 2021 | By Victoria Rees (Drug Target Review) Using X-ray crystallography and cryo-electron microscopy, researchers have elucidated the structure of the SARM1 protein, a target for neurodegeneration.
Reversible male contraceptive shows promise in pre-clinical studies 4 March 2021 | By Victoria Rees (Drug Target Review) Researchers have discovered the the compound triptonide is safe, effective and reversible as a male contraceptive in animal models.
Researchers use viruses as vectors to deliver cancer vaccines 4 March 2021 | By Victoria Rees (Drug Target Review) A team has used two viruses to administer specific tumour components in mice with cancer to stimulate their immune system.
Compounds that inhibit main protease of SARS-CoV-2 discovered 4 March 2021 | By Victoria Rees (Drug Target Review) Using high-throughput screening techniques, researchers have identified two families of active substances that block SARS-CoV-2 replication.
Researchers modifiy E. coli to produce chondroitin sulphate 3 March 2021 | By Victoria Rees (Drug Target Review) A team has created a biosynthetic pathway for E. coli that allows the bacteria to produce a common arthritis drug.
Nanoparticle COVID-19 vaccine shows promise in pre-clinical trials 3 March 2021 | By Victoria Rees (Drug Target Review) A new nanoparticle-based vaccine has demonstrated success in ferret models of COVID-19, inducing strong neutralising antibodies against SARS-CoV-2.
New drug shows potential as prophylactic for Alzheimer’s disease 3 March 2021 | By Victoria Rees (Drug Target Review) In pre-clinical studies, a novel treatment decreased plaque formation, meaning it could be used to prevent Alzheimer's disease.
In silico screening of existing drugs reveals three candidates against SARS-CoV-2 3 March 2021 | By Victoria Rees (Drug Target Review) A novel in silico approach applied to drug screening has revealed three potential candidates that may interact with multiple proteins of SARS‐CoV‐2.
