Bioprinted veins reveal new drug diffusion details
A scientific collaboration has developed vascularised 3-D bioprinted liver tissue constructs, providing more precise drug toxicity testing...
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New screening protocol for Li-Fraumeni syndrome
Researchers have found a higher than expected prevalence of cancer at baseline screening in individuals with Li-Fraumeni syndrome...
New botulinum neurotoxin discovered
Researchers have identified a new toxin, botulinum neurotoxin type X (BoNT/X), that has the potential to open up a new field of toxin therapeutics...
New cancer therapy eliminates toxic delivery vehicles for mRNA
US researchers have conjugated RNA to a molecule of folate, the folate receptor is overexpressed on cancer cells but very low on normal cells, which is why they can target a tumour and avoid healthy cells...
MRC forges two new deals with industry to speed drug discovery
The Medical Research Council has formed partnerships with UCB and AstraZeneca, the deals will help speed translation of discovery research into potential therapies...
Avenue discovered for precision cancer treatment
A novel chemical dubbed "T-REX," along with a patent-pending targeting molecule have uncovered interesting facets of several well-known cancer-cell mutations that, if present in a patient, could inform treatment options and potentially produce more favourable outcomes...
Gene-regulatory factors improve pancreatic cancer treatment
Researchers have identified two molecules that can improve the response of pancreatic cancer to a common chemotherapy drug and also predict the prognosis of pancreatic cancer patients...
Bacterial antibiotic resistance pathways identified
Researchers have described two structures and mechanisms - efflux pumps and reinforced cell walls - that certain disease-causing bacteria use to keep antibiotics away...
New marker could refine the process of producing hPSC-derived insulin cells
Scientists at the University of Copenhagen have identified a unique cell surface protein present on human pancreatic precursor cells providing for the first time a molecular handle to purify the cells whose fate is to become cells of the pancreas - including insulin producing cells.
New biomarkers found for cystic fibrosis
Canadian researchers have identified several unknown chemicals that were consistently associated with babies who had cystic fibrosis (CF), including two different drug and environmental compounds the infants secreted in sweat at much lower concentration levels...
Hamish Ryder joins Drug Target Review Advisory Board
Prior to joining CRT-DL, Dr Ryder held positions in pharmaceutical and biotech companies for over 20 years ...
Genetic testing may detect childhood epilepsy
Specific genetic factors have been found to be the cause of epilepsy in 40 percent of patients evaluated with seizures...
Metrion extends collaboration with LifeArc
Metrion Biosciences Limited and LifeArc, today announced an extension of their existing partnership...
Imfinzi wins breakthrough therapy designation
AstraZeneca and MedImmune, have today announced that the US Food and Drug Administration has granted breakthrough therapy designation for Imfinzi for the treatment of patients with locally-advanced, unresectable non-small cell lung cancer...
Cancer Research UK brings commercialisation arm in-house
The move will help funded research progress toward the development of new therapeutics
