WHO and Switzerland launch BioHub for pathogen storage and analysis 25 May 2021 | By Victoria Rees (Drug Target Review) The WHO and Swiss Confederation are set to launch a BioHub Facility, intended to facilitate the sharing of pathogens globally.
GRP78 molecular chaperone revealed as drug target for COVID-19 25 May 2021 | By Victoria Rees (Drug Target Review) Using computer modelling, a team has shown that a molecular chaperone called GRP78 could be targeted by drugs in strategies to treat COVID-19.
Nanoparticle flu vaccine shows promise at protecting mice 25 May 2021 | By Victoria Rees (Drug Target Review) Using nanoparticle liposomes, researchers have developed an experimental flu vaccine that has shown success in pre-clinical studies.
Microtitration assay developed to detect Ebola virus in vitro 24 May 2021 | By Victoria Rees (Drug Target Review) Researchers have successfully created an unbiased, high-throughput microtitration assay for the quantification of Ebola virus in cell lines.
Potential SARS-CoV-2 antiviral to be tested in human lung cells 24 May 2021 | By Victoria Rees (Drug Target Review) A synthetic antiviral named R327 has shown promise in initial tests against SARS-CoV-2 and is now advancing to the next stage of in vitro studies.
Scientists identify protein drug target to potentially treat cataracts 24 May 2021 | By Victoria Rees (Drug Target Review) Researchers have shown that a protein named aquaporin can disrupt optical development, leading to cataract formation.
High-throughput screening assay developed to discover antimalarials 21 May 2021 | By Victoria Rees (Drug Target Review) A new assay has been developed to screen for small molecule inhibitors of the Rh5 protein, which is essential for malaria parasite survival.
Computational modelling reveals SARS-CoV-2 mutation ‘hotspots’ 20 May 2021 | By Victoria Rees (Drug Target Review) A new modelling method could be used as a surveillance tool to monitor emerging infectious SARS-CoV-2 variants, scientists say.
Genomic analysis reveals cellular cause of type 1 diabetes 20 May 2021 | By Victoria Rees (Drug Target Review) Combining two genomic methodologies, researchers have shown that pancreatic exocrine cells are implicated in type 1 diabetes.
New synthetic biologic could treat obesity-related diseases 19 May 2021 | By Victoria Rees (Drug Target Review) A synthetically made glycopeptide biologic has shown promise as a treatment for obesity-related diseases in mice.
Potential COVID-19 antiviral formulated with siRNA-nanoparticles 19 May 2021 | By Victoria Rees (Drug Target Review) Scientists have created an antiviral therapy using lipid nanoparticles that deliver siRNA to the lungs to treat COVID-19 in mice.
Novel method of labelling DNA bases developed for sequencing 19 May 2021 | By Victoria Rees (Drug Target Review) Using electrochemical detection and redox labels, researchers have created a new, faster method to sequence DNA.
Novel inhibitor blocks myeloma cancer cell growth in mouse model 18 May 2021 | By Victoria Rees (Drug Target Review) Having identified the histone demethylase KDM5A as a multiple myeloma target, researchers developed a KDM5 inhibitor to treat the cancer.
Asthma vaccine shows success in pre-clinical studies 18 May 2021 | By Victoria Rees (Drug Target Review) A new conjugate vaccine has shown promise at protecting mice against the effects of cytokines associated with asthma.
Single-cell approach generates RNA atlas of breast cancer tissue 17 May 2021 | By Victoria Rees (Drug Target Review) Researchers have measured the gene expression of healthy and cancerous single cells from breast tissue, creating an 'RNA atlas'.
