Researchers improve CRISPR-Cas9 delivery efficiency 16 September 2019 | By Victoria Rees (Drug Target Review) A team has used a lentiviral capsid-based bionanoparticle system to deliver CRISPR-Cas9 gene editing therapies, reducing undesired effects.
Role of gut microbiota studied in pregnant women with lupus 16 September 2019 | By Rachael Harper (Drug Target Review) New research findings suggest that gut microbiota may regulate lupus flares in pregnant women, presenting a therapeutic target.
New strategy developed to speed up drug discovery process 16 September 2019 | By Rachael Harper (Drug Target Review) A new drug discovery strategy predicts the clinical actions of new compounds to promote desired clinical responses and avoid side effects.
Drug target discovered for pulmonary arterial hypertension 13 September 2019 | By Rachael Harper (Drug Target Review) Scientists have discovered a molecular pathway that contributes to PAH development, which may lead to a new drug target for the disease.
Study finds B cells could improve immunotherapies for cancer 13 September 2019 | By Victoria Rees (Drug Target Review) Researchers have discovered that B cells aid T cells in fighting cancer, which could be an area of development for immunotherapies.
Treatment for polycystic kidney disease shows promising results 13 September 2019 | By Rachael Harper (Drug Target Review) A potential treatment for polycystic kidney disease has shown positive results in animal testing.
Largest genome sequencing project launched in UK 13 September 2019 | By Victoria Rees (Drug Target Review) The UK Biobank, the world’s largest genetics project, will sequence 500,000 genetic samples, which will be available to researchers everywhere.
Inflammatory regulator molecule identified by study 12 September 2019 | By Victoria Rees (Drug Target Review) Researchers have discovered an enzyme that is pivotal in deciding whether cells survive or die in inflammatory diseases, so provides a drug target.
New gene therapy repairs neuron stroke damage in mice 12 September 2019 | By Victoria Rees (Drug Target Review) Researchers have developed a new treatment method which turned glial cells into functioning neurons in mice after stroke.
Nervous system discovery overturns previous theory 12 September 2019 | By Rachael Harper (Drug Target Review) A ground-breaking nervous system discovery could be significant for the treatment of different neurological diseases.
Schizophrenia gene regulator identified by study 11 September 2019 | By Victoria Rees (Drug Target Review) Using both computational models and stem cell-based experiments, researchers have identified a gene regulator of schizophrenia.
CAR T-cell therapy could be harnessed to treat heart disease 11 September 2019 | By Rachael Harper (Drug Target Review) New study finds immunotherapy reduces cardiac fibrosis and restores heart function in mice after cardiac injury.
New biological targets could lead to therapies for drug-resistant cancers 11 September 2019 | By Rachael Harper (Drug Target Review) A study on how Polycombs regulate cellular identity could lead to alternative treatments for patients with drug-resistant cancer.
Protein vital for breast cancer metastasis discovered 11 September 2019 | By Victoria Rees (Drug Target Review) A research team have identified a protein that binds breast cancer cells together, allowing them to metastasise, which could be significant in the development of cancer therapies.
Genetic alterations linked to drug resistance revealed by liquid biopsies 10 September 2019 | By Rachael Harper (Drug Target Review) A clinical study comparing liquid and tissue biopsies finds multiple resistance mechanisms in individual patients.
