Process that immune cells use to detect infections and cancers discovered
Researchers have discovered how gamma-delta T cells become activated which could lead to the development of new and improved immunotherapy treatments.
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Islet protective factor GDF15 reduces development of type 1 diabetes in mice
Researchers have discovered that type 1 diabetes patients have low levels of growth differentiation factor 15 (GDF15) in their pancreatic β cells, unlocking a potential alternative to life-long type 1 diabetes disease management.
Common prostate cancer mutation inspires path to new anti-cancer therapy
PPP2R2A gene allele deletion in prostate cancers promotes the uncontrolled division of cells, reinstatement of its protein causes cancer cell death, so could provide a new therapeutic option.
Immune cells grown in dish from pluripotent stem cells
In a world first, researchers have grown immune cells from pluripotent stem cells in a dish, which could be used to develop immunotherapies or to test autoimmune disease treatments.
New compounds developed to block cancer growth regulator FOXM1
A study has demonstrated the success of new compounds that prevent FOXM1, a transcription factor, from increasing cancer proliferation.
How dying cells prevent autoimmune reactions could inform treatments
The interaction between proteins on apoptotic cells and receptors of the murine immune system prevents autoimmune reactions and could be the basis for new treatments, according to scientists.
HDAC3 inhibitors: a potential treatment for non-Hodgkin lymphomas?
A murine study found histone deacetylase 3 (HDAC3) inhibitors reverse epigenetic changes caused by CREBBP mutations found in lymphomas and could be developed into a novel therapy.
Study paves way for new vaccines to protect infants against infections
An mRNA vaccine has been developed which has elicited strong immune responses in mice in the presence of maternal antibodies.
New virus surface characterisation technique developed
Researchers have demonstrated the success of a new single-particle method of studying the surface of viruses, which could improve vaccine purification and the development of gene therapies.
SVC112 molecule reduces effects of cancer stem cells with little toxicity
A study has shown that the SVC112 molecule can prevent cancer stem cells from producing more tumour cells in cell lines and mice, with no impact on healthy cells.
Siah2 protein discovered as a regulator of the immune system
A new study has revealed that the Siah2 protein is crucial to control Tregs in mice, which can reduce the effectiveness of immunotherapies.
Genes found to slow down the development of intestinal tumours
Scientists have found that when two specific genes are deleted in benign tumour tissue in the intestines, it more rapidly develops into a tumour that is more likely to become cancerous.
Universal influenza vaccine protects mice against multiple strains of flu
A new double-layered nanoparticle vaccine protected mice against six strains of the flu and may provide the basis for the first universal vaccine against seasonal influenza, according to research.
Blimp-1 identified as driver of T-cell activity against cancer
A study has shown that T cells are driven to attack tumours by IL-2 and Blimp-1 in mice, which researchers say could form the basis of cancer therapies.
Study identifies drug design applications as main recipient of AI investment
Research suggests that over half of the total $5.2bn investment for artificial intelligence in pharma went to drug design applications in 2019, but overall investment is slowing.
