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ebook: Antibody detection for cancer research
Gain more insight into immune-tumor interactions and learn how antibody detection techniques like multiplexing is advancing immunotherapies.
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Targets
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New developments in the research field of immuno-oncology
The exciting potential of immunotherapy for cancer treatment continues its exploration and here, Drug Target Review investigates three of the latest pre-clinical developments in immuno-oncology research.
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Article: Finding a (biomarker) needle in the haystack
Summary of a neurology publication by Alnylam Pharmaceuticals: large-scale protein screening identifies novel biomarker for onset and progression of lethal ATTRv amyloidosis.
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Avocado compound targets enzyme critical to leukaemia cell growth
The fat molecule avocatin B, found in avocados, was shown to inhibit VLCAD, an enzyme vital for leukaemia cell metabolism.
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Raman spectroscopy platform developed to characterise IDPs
Optical tweezers-coupled Raman spectroscopy has been used to reveal the structure of alpha-synuclein, an IDP linked to Parkinson's disease.
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Sanguinarine shows promise against triple-negative breast cancer
A new study in cell cultures has shown that the sanguinarine plant compound could be used to treat people with triple-negative breast cancer.
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Hepatitis C drugs shown to boost remdesivir’s activity against SARS-CoV-2
Four hepatitis C drugs have demonstrated promise as boosters to increase the efficacy of remdesivir against SARS-CoV-2 by as much as tenfold.
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Study points to treatment approaches for advanced small-cell lung cancer
Having sequenced samples of advanced small-cell lung cancer, researchers have identified patterns linked to resistance to certain therapies.
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Nanobody cocktail shown to block SARS-CoV-2 infection in mouse models
Researchers have used cryo-EM to show that a new nanobody cocktail can bind to the S protein of SARS-CoV-2, neutralising the coronavirus.
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Inhibiting METTL3 enzyme combats acute myeloid leukaemia in mice
Scientists have developed a drug called STM2457 which inhibits a key enzyme involved in acute myeloid leukaemia.
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Role of macrophages in blood flow regulation after tissue damage revealed
Researchers have shown in mice that macrophages play a role in controlling blood flow and healing following tissue damage.
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DNA vaccine protects non-human primates against MERS, study shows
A candidate vaccine has shown potential against MERS in non-human primates, when administered intradermally.
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Experimental drug shown to reverse effects of Alzheimer’s in mice
Oral doses of a new drug named CA administered to mouse models led to improvements in Alzheimer's disease, including memory.
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Compound that targets BRAT1 protein could be used to kill cancer cells
Having synthesised the curcusone D compound, researchers demonstrated its promise as the first BRAT1 inhibitor, making it a potential cancer therapy.
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Structure of PLEKHA7 protein domain imaged, presenting cancer drug target
A range of imaging and computational techniques were used by researchers to discover the structure of the PH domain of PLEKHA7.
