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Monoclonal antibodies prevent COVID-19 inflammation in macaques

2 November 2021 | By Anna Begley (Drug Target Review)

Neutralising monoclonal antibodies protected aged macaque monkeys from SARS-CoV-2 and reduced inflammation, including in cerebrospinal fluid, a new study has shown.

news

Pathway and enzyme responsible for CKD thrombosis identified

2 November 2021 | By Anna Begley (Drug Target Review)

Scientists have discovered a novel pathway and enzyme that causes thrombosis in chronic kidney disease (CKD) patients, indicating a new drug target.

podcast

Episode 3 – Cell & gene therapy with Dr Sam Wadsworth, Ultragenyx Pharmaceutical & Dr Eric Ostertag, Poseida Therapeutics

1 November 2021 | By Drug Target Review

Tune in to this podcast to learn about AAV vectors for gene therapy delivery and engineering CAR T cells against solid tumours.

news

GLP-1 and GIP receptor agonists reduce mouse obesity in pre-clinical study

1 November 2021 | By Anna Begley (Drug Target Review)

Treatment with Viking Therapeutics' dual agonists resulted in mean reductions in body weight of up to 27 percent compared to semaglutide-treated animals.

MRI scan of brain with Alzheimer's disease

news

Scientists eliminate key Alzheimer’s feature in animal model

1 November 2021 | By Anna Begley (Drug Target Review)

Turning off NHE6 in mice in pre-clinical studies prevented amyloid beta aggregation, a key feature of Alzheimer's disease, pointing to new therapies.

news

$9 million grant awarded to uncover whether Parkinson’s starts in the nose

29 October 2021 | By Anna Begley (Drug Target Review)

A new grant will allow an international team to determine if scent-processing nerves in the nose play a role in the development of Parkinson's and could aid in the development of novel therapeutics.

Antibiotic resistant bacteria in biofilm

news

Machine learning models predict antibiotic resistance spread

29 October 2021 | By Anna Begley (Drug Target Review)

Scientists have used several machine learning models to predict bacterial gene exchange, which could reveal novel antibiotic targets.

Red blood cells flowing with too many white blood cells, indicating leukaemia

news

Albert Einstein researcher receives NIC award to study two blood cancers

28 October 2021 | By Anna Begley (Drug Target Review)

Professor Ulrich G Steidl received the National Institute of Cancer's Outstanding Investigator Award to study myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML).

news

Scientists target ALS and dementia RNA using novel molecule

28 October 2021 | By Anna Begley (Drug Target Review)

The small molecule successfully targeted the C9orf72 gene that causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

T cell lymphocyte with receptors to kill cancer cell in cancer i

news

Raman spectroscopy used to determine immunotherapy effectiveness

28 October 2021 | By Anna Begley (Drug Target Review)

Researchers used Raman spectroscopy to monitor immunotherapy response in mice, potentially improving cancer treatments in the future.

Computer with many medical symbols on screen

news

Groundbreaking data tool may uncover novel class of GPCRs

27 October 2021 | By Anna Begley (Drug Target Review)

A new computer-aided tool maps allosteric sites in G protein-coupled receptors to search for allosteric drugs to treat a range of diseases.

Mouse on lab tubes with DNA molecule in background

news

Experimental mouse model reveals potential progeria treatment strategy

27 October 2021 | By Anna Begley (Drug Target Review)

Scientists have found that Hutchinson-Gilford Progeria Syndrome (HGPS) can be prevented with treatments targeting the cardiovascular system using a novel mouse model.

news

Specific mechanism found to control transition from acute to chronic pain

27 October 2021 | By Anna Begley (Drug Target Review)

A new study is the first to identify N-acylethanolamine acid amidase as a new drug target to treat different forms of chronic pain.

Capturing biological complexity to empower biomarker discovery

webinar

Capturing biological complexity to empower biomarker discovery

27 October 2021 | By Takara Bio

Sign up for this free webinar and discover how refined cell atlases can provide comprehensive roadmaps for health and disease.

news

Molecular targets for breast cancer relapse identified in new study

26 October 2021 | By Anna Begley (Drug Target Review)

German, Norwegian and British scientists have identified molecular targets for therapies that could prevent breast cancer recurrence.

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