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Nobel Prize in Chemistry awarded to scientists who discovered CRISPR-Cas9

12 October 2020 | By Victoria Rees (Drug Target Review)

Emmanuelle Charpentier and Jennifer Doudna have been given the 2020 Nobel Prize in Chemistry for their discovery and development of CRISPR-Cas9 genome editing.

SARS-CoV-2 particles in grey and red - SARS-CoV-2 is the virus that causes COVID-19

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Researchers suggest blocking factor D protein could combat SARS-CoV-2

9 October 2020 | By Victoria Rees (Drug Target Review)

A team has said that inhibiting the factor D protein could prevent SARS-CoV-2 from turning the immune system against healthy cells.

Futuristic image - DNA stand with scissors about to cut it - idea of CRISPR gene editing

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CRISPR used to eliminate cancers caused by fusion genes

9 October 2020 | By Hannah Balfour (Drug Target Review)

Using CRISPR to cut out fusion genes, scientists were able to specifically induce cancer cell death in murine models of sarcoma and leukaemia.

EEG waves indicating an epileptic seizure overlaid with a brain

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Single-nucleus transcriptomics reveals novel epilepsy targets

8 October 2020 | By Hannah Balfour (Drug Target Review)

Study reveals which neurons are most affected by epilepsy, presenting novel targets for seizure drug discovery and development.

news

SARS-CoV-2 mechanism of infection revealed using cryo-electron microscopy

8 October 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that the surface of SARS-CoV-2 can take on at least 10 different structural states when in contact with ACE2.

Syringe drawing liquid from a vial labelled 'REMDESIVIR', on a background of abstract SARS-CoV-2 particles [Credit: ffikretow@hotmail.com / Shutterstock.com].

news

Researchers identify a potential remdesivir resistance mechanism in SARS-CoV-2

8 October 2020 | By Hannah Balfour (Drug Target Review)

Exploring how the Ebola virus develops remdesivir resistance has highlighted a mutation that could allow SARS-CoV-2 to do the same.

webinar

SARS-CoV-2 testing: automation of high-throughput qPCR and COVID-seq

8 October 2020 | By SPT Labtech

In this on-demand webinar, we explored the various methods of COVID-19 testing: qPCR, COVID-seq, antigen and antibody detection, and others. Coupling these assays with low volume, high speed automation has made great strides toward achieving the high-throughput testing essential to ending this pandemic.

news

Gramicidin A antibiotic analogues safe for human cells developed

6 October 2020 | By Victoria Rees (Drug Target Review)

A team has developed 10 new versions of the antibiotic gramicidin A, which they say should be safe for use in pills or injections.

Ovarian cancer cells forming a cancer spheroid as they grow within the peptide-protein co-assembling material [Credit: Alvaro Mata].

news

Novel tumour spheroids could improve ovarian cancer treatments

5 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers have developed a new self-assembling three-dimensional (3D) ovarian cancer tumour model to recreate the in vitro disease more accurately.

SARS-CoV-2 - COVID-19 - inhibition by LY6E

news

Team identifies T-cell epitopes to inform COVID-19 vaccine development

2 October 2020 | By Victoria Rees (Drug Target Review)

Researchers studied 180 convalescent COVID-19 patients to reveal T-cell epitopes that they say can be targeted by a vaccine.

stand of DNA behing a side on view of the human head with the brain highlighted in red

news

Epigenetic marks could be the target of future Alzheimer’s therapies

2 October 2020 | By Hannah Balfour (Drug Target Review)

New findings suggest that late-onset Alzheimer's Disease (AD) is driven by epigenetic changes in the brain.

news

New thermofluidic technology allows researchers to bioprint cells in 3D

1 October 2020 | By Victoria Rees (Drug Target Review)

Researchers have used heat to develop a new way to bioengineer cells that grow a certain way and bioprint 3D tissues.

news

Researchers identify mutations in single genes that lead to cerebral palsy

1 October 2020 | By Victoria Rees (Drug Target Review)

A new study has shown that the mutated FBXO31 and RHOB genes can each alone cause cerebral palsy, offering potential drug targets.

close up photo of a syringe drawing liquid from a medicine vial

news

Using CRISPR to develop a cutaneous leishmaniasis vaccine

30 September 2020 | By Hannah Balfour (Drug Target Review)

Researchers used CRISPR gene-editing to develop a vaccine able to protect against the spread of the Leishmania major parasite which causes cutaneous leishmaniasis.

news

Researchers map pathoconnectome of eye disease and retinal circuitry

30 September 2020 | By Victoria Rees (Drug Target Review)

Scientists have produced the first pathoconnectome - an open access map for other researchers that shows how eye disease can alter retinal circuitry.

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