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Imaging technique reveals how HIV drugs bind to viral structure
A new study has shown in three dimensions how drugs bind to HIV, which could be used to improve the design of drugs or develop novel therapies.
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Researchers suggest IMPDH enzyme could be used to target sleeping sickness
Research into drug targets for sleeping sickness parasite T. brucei has characterised the inosine-5'-monophosphate dehydrogenase (IMPDH) enzyme, providing a possible novel avenue for therapies.
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Diabetes-related proteins examined for the first time at high resolution
A key receptor has been examined for the first time at high resolution which could lead to better treatments for conditions such as type 2 diabetes.
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New capillary model could provide new therapies for malaria
Researchers have produced a capillary model which allows investigation of the dynamics of blood flow obstruction in real scale and could be used to test new therapies for P. falciparum malaria.
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Lower levels of SV2A protein identified as drug target for schizophrenia
Using brain scans, a study has shown that schizophrenia patients have lower levels of the protein SV2A in their brains which presents a drug target.
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Deep learning network used to model protein complexes
A new study has developed a deep learning approach that analyses protein interactions, which could improve the design of drugs in the future.
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New virus surface characterisation technique developed
Researchers have demonstrated the success of a new single-particle method of studying the surface of viruses, which could improve vaccine purification and the development of gene therapies.
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Researchers image C. diff toxins to aid in drug design
A new study has used several imaging techniques to characterise C. diff toxins, which could help to design drugs to combat infections from the bacteria.
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Novel spectrometer technology can analyse molecular composition of biological samples
A new spectrometer laser system has been developed by researchers in Germany, which can detect specific compounds in biological samples.
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First images of an ‘upgraded’ CRISPR tool captured
Researchers have utilised cryo-electron microscopy and used the images they captured with an electron microscope to generate atomic resolution models of the INTEGRATE system.
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Researchers find 150 possible inhibitors to fight Nipah virus
A group of scientists from India have used 3D imaging of the Nipah virus to discover potential inhibitors for the disease.
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Advanced imaging technique could be used to image living cells faster
Researchers have used ghost imaging to enhance the imaging speed of nanoscopy, which could make it possible to capture processes in living cells at speeds not previously possible.
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Appearance of proteins used to predict function with machine learning
Researchers have used a machine-learning algorithm to study protein appearance and discover common features that influence function, which could be used to design artificial cells.
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Structure of key pneumonia virus enzyme uncovered
Scientists have used cryo-electron microscopy to clarify the structure of one of the key components of RSV and HMPV, which could lead to new therapies for the viruses.
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Drug Target Review – Issue 4 2019
This issue includes a discussion on the future of high-throughput screening through collaboration, an analysis of mass spectrometry as a structural biology tool and an exploration of the challenges of hit-to-lead when researching tropical diseases. Also in the issue are articles on immuno-oncology and assays.
