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Guide: Five ways biophysical tools help brain studies
Learn why researchers turned to biophysical methods to expose the molecular mechanisms of neurodegenerative diseases.
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Imaging
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Expert view: From 3D high throughput to simple automated imaging: cellular imaging within reach of every laboratory
Our Ability to image cells has come a long way since the pioneering days of Galileo Galilei and Antonie van Leeuwenhoek.
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Imaging In-Depth Focus 2020
The articles in this in-depth focus discuss the difficulties in deciding what information to capture when imaging three-dimensional (3D) cell models and the use of non-invasive imaging techniques to discover small molecule drugs to control protein translation.
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Drug Target Review – Issue 2 2020
In this issue authors discuss the development of COVID-19 antibody therapies, how high-throughput screening enhances research at the Crick Institute and why combinations of immuno-oncology drugs could revolutionise treatment of advanced cancers. Also included in the issue are articles on stem cells and imaging.
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Dynamics of GPCRs revealed using combination of approaches
A team used both structural and spectroscopic techniques to study the dynamics of cell surface G-protein coupled receptors (GPCRs).
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ebook: How to start your own lab
Learn practical tips from eight Principal Investigators about how to start your own lab.
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Novel method enables mapping of signalling within living cells
A novel microscopy method has enabled researchers to study the flow of signalling information within living cells and could enhance our understanding of cancer metastasis.
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ebook: High-content analysis and infectious disease
Learn how you could use high-content analysis for functional & phenotypic assays in your infectious disease research or drug discovery.
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Mass spec used to reveal glycan structures of COVID-19 Spike protein
High-resolution mass spectrometry has been used by researchers to map the glycan-processing states of the Spike protein of the SARS-CoV-2 virus, which causes COVID-19.
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Researchers reveal structure of mega-enzymes from bacteria and fungi
Researchers have uncovered the structure of nonribosomal peptide synthetases (NRPSs), an important ingredient in drug production.
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Self-aligning smart microscope achieves unprecedented resolution
The developers of the ultra-precise single-molecule microscope demonstrated it can resolve interactions between molecules within living cells and is compatible with existing microscopes.
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New label-free microscopy method enables imaging inside living cells
By combining quantitative phase microscopy and molecular vibrational imaging, researchers have created a new label-free microscopy technique.
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Binding site of drug compound and tumour suppressor protein revealed
Using cyro-electron microscopy, researchers have imaged the binding site between a molecule and the tumour suppressor protein PP2A, enabling optimisation of the drug compound.
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Nanobodies developed to image COVID-19 Spike protein
Researchers in the UK have selected nanobodies that bind with high affinity to the Spike protein on the COVID-19 coronavirus, enabling stabilisation for imaging.
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VP3 protein: revealing the structure of a potential rotavirus drug target
Researchers hope that by revealing the rotavirus VP3 protein structure and mRNA capping functions, novel antivirals could be designed to prevent or combat rotavirus infections.
