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Drug repurposing approaches to fast track development of new therapies for COVID-19

26 June 2020 | By Tecan

This webinar described the recent efforts to identify small molecule therapeutics for the treatment of SARS-CoV-2 infection and COVID-19 disease.

news

Promising COVID-19 drug candidate identified by virtual screening

25 June 2020 | By Victoria Rees (Drug Target Review)

After virtually screening 640 existing drug compounds, researchers have revealed that PC786 potently targets several SARS-CoV-2 receptors, making it a candidate to fight COVID-19.

news

Over 718 drugs in pipeline as potential COVID-19 treatments, says report

25 June 2020 | By Victoria Rees (Drug Target Review)

New research has found that of the 718 pipeline drugs associated with COVID-19, 70 percent are currently in the discovery or pre-clinical stages.

news

Novel compound could treat type 2 diabetes without common side effects

24 June 2020 | By Victoria Rees (Drug Target Review)

Two molecules combined into a new substance to treat type 2 diabetes lowered blood sugar in shrew models without causing nausea, vomiting and weight loss.

whitepaper

ebook: The researcher’s guide to measuring binding affinity

24 June 2020 | By NanoTemper Technologies

Learn why measuring binding affinity is key to helping you decide the next steps in your research and what technologies are available to measure it.

news

Screening reveals nelfinavir and amodiaquine combat COVID-19 in cell cultures

18 June 2020 | By Victoria Rees (Drug Target Review)

Researchers who screened 136 broad-spectrum antivirals identified six with the most activity against COVID-19 and an optimum combination of two to fight the virus.

whitepaper

ebook: The definitive guide to understanding protein stability

16 June 2020 | By NanoTemper Technologies

Learn how to measure protein stability, why it’s important, and what the key technologies are available to measure it.

webinar

Improving cell-based assays and their future in drug discovery

15 June 2020 | By Horizon Discovery

Watch our on-demand webinar with Horizon Discovery which summarises the challenges in translating promising pre-clinical therapeutic candidates into clinical success.

news

Naphthalene-based PLpro inhibitors show potential as COVID-19 therapeutics

12 June 2020 | By Victoria Rees (Drug Target Review)

A group of small molecules called naphthalene-based PLpro inhibitors have been shown to block the activity of a SARS-CoV-2 protein, demonstrating potential as COVID-19 therapeutics.

video

Video: ESHG 2019 conference discussion panel: automated sample preparation

10 June 2020 | By Thermo Fisher Scientfic

A result is only as good as the sample preparation that preceded it.

video

Video: Overview of the KingFisher^TM instruments

10 June 2020 | By Thermo Fisher Scientific

ESHG 2019: Automated sample preparation using magnetic bead technology and KingFisher instruments.

video

Video: Isolate Circulating tumor cells using the KingFisher

9 June 2020 | By Thermo Fisher Scientfic

New opportunities for liquid biopsy: At automated workflow for isolating circulating tumor cells using KingFisher instruments.

whitepaper

ebook: How FBDD improves hit rates & delivers high-value targets

8 June 2020 | By NanoTemper Technologies

Learn how fragment-based drug discovery improves hit rates and delivers higher-value targets using various biophysical methods.

article

High-throughput screening as a method for discovering new drugs

4 June 2020 | By Mathew Lloyd (University of Bath)

High-throughput screening is a common method of identifying lead compounds for drug development. The most common targets are enzymes – catalytic proteins that perform chemical reactions in the cell. In this article, Matthew Lloyd discusses the opportunities and challenges associated with this approach.

whitepaper

Guide: Five ways biophysical tools help brain studies

3 June 2020 | By NanoTemper Technologies

Learn why researchers turned to biophysical methods to expose the molecular mechanisms of neurodegenerative diseases.

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