news Novel targeted treatment shows efficacy in treating high-risk solid tumours 25 August 2020 | By Hannah Balfour (Drug Target Review) The prodrug developed by researchers caused long-term remission in all murine models of high-risk or drug-resistant cancers with fewer side-effects than a comparable drug.
news Researchers suggest IgA antibodies are better at neutralising SARS-CoV-2 25 August 2020 | By Hannah Balfour (Drug Target Review) Scientists have developed a novel secretory immunoglobulin A (sIgA) serotype antibody that binds more effectively to the spike protein of SARS-CoV-2 than some IgG antibodies.
news AI holds promise to accelerate drug repurposing for COVID-19 20 August 2020 | By Victoria Rees (Drug Target Review) According to a new report, artificial intelligence (AI) is vital for the rapid identification of drugs that can be repurposed to combat COVID-19.
news Drug candidate outperforms remdesivir as COVID-19 antiviral in cell assays 18 August 2020 | By Victoria Rees (Drug Target Review) A compound called BOLD-100, which has shown efficacy against COVID-19 in pre-clinical trials, has now outperformed remdesivir in a cytopathic effect assay.
news Method to synthetically produce terpenes developed by researchers 18 August 2020 | By Victoria Rees (Drug Target Review) Scientists have developed a synthetic biology process using enzymes to create three families of terpenes, potential starting points for new drugs.
news Machine learning reveals potential COVID-19 therapeutic compounds 13 August 2020 | By Victoria Rees (Drug Target Review) A drug screen using machine learning has identified hundreds of potential drugs that could be used to treat COVID-19, researchers say.
news Novel molecule effectively treats arthritis in mice, study shows 12 August 2020 | By Victoria Rees (Drug Target Review) A molecule called TPPU has been shown to inhibit an enzyme that plays a key role in inflammation, successfully treating arthritis in mice.
news Potential COVID-19 treatment and vaccine combination shows success in cells 12 August 2020 | By Victoria Rees (Drug Target Review) A possible treatment and vaccine combination for COVID-19 has shown positive results in pre-clinical studies using human cells.
news Drug candidate for memory loss associated with Alzheimer’s developed 5 August 2020 | By Victoria Rees (Drug Target Review) A drug called CMS121 given to mice with Alzheimer's-like disease treated their memory loss, allowing them to perform the same as healthy control mice in tests.
news Decoy ACE2 receptors show promise as COVID-19 treatment in cell cultures 5 August 2020 | By Victoria Rees (Drug Target Review) A new decoy receptor of ACE2 has been created which binds to and neutralises COVID-19 in live tissue cultures, preventing cells from becoming infected.
news High-throughput screening reveals 21 drugs with activity against COVID-19 28 July 2020 | By Victoria Rees (Drug Target Review) After screening 12,000 existing drugs, scientists have identified 21 which prevent the replication of SARS-CoV-2 in concentrations safe for patients.
news Nanoparticle COVID-19 vaccine elicits immune response in pre-clinical studies 21 July 2020 | By Hannah Balfour (Drug Target Review) The vaccine candidate repRNA-CoV2S elicited both antibody and T cell responses after just two injections in mice and macaques.
news Experimental drug reduces zika virus replication and protects developing mouse pups 21 July 2020 | By Hannah Balfour (Drug Target Review) The novel aryl hydrocarbon receptor (AHR) inhibiting drug slowed zika virus replication and prevented mouse foetuses malforming in infected mothers.
whitepaper Whitepaper: Big data and connected tools 21 July 2020 | By Gilson As more of the small devices in the lab become connected, more laboratory workflows will be observable, and variability will be better understood.
whitepaper Case Study: Lab digitalisation and interoperability 20 July 2020 | By Gilson Learn how one lab is saving time, improving traceability, and standardising protocols by using connected tools and recording all workflows digitally.
