Kenji Schorpp (HelmholtzZentrum Munchen)

article

HTS assays for the identification of small-molecule inhibitors of deubiquitinating enzymes

4 December 2016 | By Elisabeth Weber (HelmholtzZentrum Munchen), Kamyar Hadian (HelmholtzZentrum Munchen), Kenji Schorpp (HelmholtzZentrum Munchen)

The covalent modification of proteins by the attachment of ubiquitin (ubiquitination) is best known for its function to label proteins for proteasomal degradation. However, ubiquitination also plays non-proteasomal roles during signal transduction, DNA repair and protein sorting...

article

Targeting the ubiquitin-proteasome system

11 May 2014 | By Kamyar Hadian (HelmholtzZentrum Munchen), Kenji Schorpp (HelmholtzZentrum Munchen)

The ubiquitin-proteasome system (UPS) is a hierarchical enzymatic cascade that plays an essential role in a broad range of cellular pathways and is found in cytoplasmic and nuclear actions of all eukaryotic cells...

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Kenji Schorpp (HelmholtzZentrum Munchen)

HTS assays for the identification of small-molecule inhibitors of deubiquitinating enzymes

Targeting the ubiquitin-proteasome system