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Hannah Balfour (Drug Target Review)

3D illustration of gold nanoparticles falling from above onto a shiny gold surface

Developing bioenergetic nanocatalysts, a novel approach to treat neurodegeneration

8 March 2021 | By Hannah Balfour (Drug Target Review)

Mark Mortenson, CSO of Clene Nanomedicine, discusses the use of proprietary gold nanocrystals as catalysts to prevent the progression of, and act as a treatment for, neurodegenerative disease.

3D illustration of a tumour cell under cross hares

article

NOX5: a novel target for sensitising melanoma to therapies

19 February 2021 | By Hannah Balfour (Drug Target Review)

Vito Quaranta, professor of biochemistry and pharmacology, discusses how cancerous cells adopting novel mechanisms of energy production could be sensitised to existing therapies with a focus on melanoma.

article

Advancing neutralising antibody therapies for COVID-19

17 February 2021 | By Hannah Balfour (Drug Target Review)

In this article, Ian Chan, Chief Executive Officer and Co-Founder of biotech company Abpro, discusses the development of neutralising antibodies for SARS-CoV-2. Abpro’s neutralising antibody candidate ABP 300 is currently in Phase II/III trials.

close up of an old person's hands holding a walking stick - idea of age-related diseases/disorders

news

Inhibiting the GLS1 enzyme could improve numerous age-associated disorders, finds study

5 February 2021 | By Hannah Balfour (Drug Target Review)

In a new study, inhibitors of the GLS1 enzyme caused the death of senescent cells and relieved the symptoms of various age-related diseases in mice.

news

Novel DNA-based COVID-19 vaccines induce immune responses in mice

5 February 2021 | By Hannah Balfour (Drug Target Review)

The DREP-S vaccine candidate was found to be the most potent of the two investigational vaccine prototypes, eliciting high titers of SARS-CoV-2 neutralising antibodies after a single dose.

article

Could downregulating the Drp1 protein prevent Alzheimer’s progression?

4 February 2021 | By Hannah Balfour (Drug Target Review)

In this article, we explore the findings of a study that suggests a newly identified pathway, the Drp1-HK1-NLRP3 signalling axis, could be a promising target for therapies to prevent Alzheimer’s disease progression.

news

Tissue damage and genetic mutations interact to drive pancreatic cancer, finds study

4 February 2021 | By Hannah Balfour (Drug Target Review)

New research shows tissue damage to cells carrying KRAS mutations induces epigenetic changes that promote pancreatic cancer.

news

Researchers identify how Zika infects foetuses and a potential drug to prevent it

4 February 2021 | By Hannah Balfour (Drug Target Review)

According to scientists, maternal cells act as a reservoir for Zika, enabling the virus to pass from mother to foetus during pregnancy.

Coronavirus particle being injected by a syringe labelled 'Covid-19 Vaccine'

news

COVID-19 vaccine candidate stimulates neutralising antibody production in vivo

3 February 2021 | By Hannah Balfour (Drug Target Review)

The novel haptenised SARS-CoV-2 s-Spike vaccine, BVX-0320, stimulated mice to create neutralising antibodies that were able to reduce SARS-CoV-2 plaques in a neutralisation test.

Digestive tract drawn on a chalk board in white with various colours and shapes of microbes

news

Could bile acids play a role in Parkinson’s pathogenesis?

3 February 2021 | By Hannah Balfour (Drug Target Review)

A new study suggests bile acids may act as a valuable biomarker for diagnosing and tracking the progression of Parkinson's disease.

news

HIV drugs could be repurposed to prevent the onset of macular degeneration

2 February 2021 | By Hannah Balfour (Drug Target Review)

Analysis reveals people taking nucleoside reverse transcriptase inhibitors are significantly less likely to develop dry macular degeneration, a leading cause of age-related vision loss.

Computer screen displaying DNA strand, human body and organs and various tablets - idea of technology for medicine screening

news

Novel AI tool takes a DeepCE dive into potential drugs for COVID-19

2 February 2021 | By Hannah Balfour (Drug Target Review)

A new phenotype-based compound screening technology, called DeepCE, identified 10 compounds that could be repurposed for COVID-19.

news

Targeting the HCF-1 protein causes cancerous cells to self-destruct

1 February 2021 | By Hannah Balfour (Drug Target Review)

Disrupting the interaction between the MYC oncogene and its co-factor, host cell factor (HCF)–1, was sufficient to cause Burkitt’s lymphoma cells to self-destruct in vivo.

Coronavirus particles in green with purple extracellular proteins

news

N439K variant of SARS-CoV-2 is resistant to some neutralising antibodies, shows study

1 February 2021 | By Hannah Balfour (Drug Target Review)

The N439K mutation improves the interaction between SARS-CoV-2 Spike protein and the viral receptor ACE2 and eludes antibody-mediated immunity, say investigators.

news

Biomarkers predict Alzheimer’s five years before onset

29 January 2021 | By Hannah Balfour (Drug Target Review)

The discovery of early plasma biomarkers for Alzheimer's disease could transform outcomes by enabling patients to begin treatment early.

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Hannah Balfour (Drug Target Review)