Dr Agnes Martin

article

A pragmatic approach to hit validation following biochemical high-throughput screening

12 December 2017 | By Dr Agnes Martin, Dr Laurent Rigoreau, Dr Sheila McLoughlin

Progressing actives from a high-throughput screen (HTS) of a target protein into suitable starting points for lead identification is fraught with pitfalls. The volume and quality of the HTS output is a function of the quality of the screening library, as well as specific properties of both the target and…

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Dr Agnes Martin

A pragmatic approach to hit validation following biochemical high-throughput screening